Publications by authors named "John Hinkle"
Purpose: To evaluate anatomic outcomes and surgeon response following the use of microserrated (Sharkskin, Alcon, Forth Worth, TX) internal limiting membrane (ILM) forceps compared with conventional (Grieshaber; Alcon) ILM forceps for peeling of the ILM.
Methods: Patients were prospectively assigned in a 1:1 randomized fashion to undergo ILM peeling using microserrated forceps or conventional forceps. Rates of retinal hemorrhages, deep retinal grasps, ILM regrasping, time to ILM removal, and surgeon questionnaire comparing the use of microserrated and conventional ILM forceps were analyzed.
Article Synopsis
- * It included 53 eyes from 47 patients who had not been followed up for at least 180 days, and findings showed that visual acuity remained stable over time after their return visit.
- * Notably, some patients experienced increased IOP at their first return visit; however, no patients required surgery, and those with diabetic macular edema showed a more significant rise in IOP compared to other conditions.
Purpose: To evaluate features of infectious panuveitis associated with multiple pathogens detected by ocular fluid sampling.
Methods: Single-center, retrospective, consecutive case series of patients with aqueous/vitreous polymerase chain reaction testing with >1 positive result in a single sample from 2001 to 2021.
Results: Of 1,588 polymerase chain reaction samples, 28 (1.
The Guaymas Basin in the Gulf of California is characterized by active seafloor spreading, the rapid deposition of organic-rich sediments, steep geothermal gradients, and abundant methane of mixed thermogenic and microbial origin. Subsurface sediment samples from eight drilling sites with distinct geochemical and thermal profiles were selected for DNA extraction and PCR amplification to explore the diversity of methane-cycling archaea in the Guaymas Basin subsurface. We performed PCR amplifications with general (mcrIRD), and ANME-1 specific primers that target the alpha (α) subunit of methyl coenzyme M reductase ().
View Article and Find Full Text PDFPurpose: The United States (US) federal government uses health provider shortage areas (HPSAs) to define patient accessibility to primary care physicians. It is unclear whether HPSAs can be applied to eye care providers (ECPs). Our study determined the applicability of federal HPSA designations to ECP availability in the US.
View Article and Find Full Text PDFPurpose: To report a case series of endophthalmitis associated with intravitreal dexamethasone injections in a single practice and to discuss the clinical findings and visual outcomes of each case.
Methods: All endophthalmitis cases following intravitreal dexamethasone injections performed from January 1, 2014 to October 20, 2020 were identified using Wills Eye/MidAtlantic billing records. The diagnosis, clinical information, and microbiology were confirmed for each case.
Purpose: To evaluate seasonal and environmental variations on the incidence and outcomes of postinjection endophthalmitis.
Methods: A single-center, retrospective cohort study was conducted including all patients diagnosed with post-injection endophthalmitis between 2013-2018. Associations between climate variables and endophthalmitis incidence were evaluated.
Purpose: To characterize how community mobility patterns across the United States correlate with local changes in retina visits during the pandemic.
Methods: Outpatient retina clinic visits were linked to population mobility by combining multiple public data sets, including the Google Community Mobility Reports and data from the Centers for Disease Control and Infection. Percentage change from baseline in daily-average number of retina visits by county and mobility were measured by county.
This study aimed to evaluate the experiences and preferences of ophthalmology fellowship applicants utilizing a virtual interview format. Present study is a cross-sectional study. All fellowship applicants to Wills Eye Hospital during 2020 to 2021 application cycle were included.
View Article and Find Full Text PDFPurpose Of Review: Retained lens fragments are a relatively rare occurrence after cataract surgery. While no definite guidelines for the surgical management or timing of surgery of this complication exist, surgery is indicated for patients with large lens fragments, persistent inflammation, secondary glaucoma, corneal edema, retinal tears or detachments, and associated endophthalmitis. The aim of this review is to summarize the current surgical management of retained lens material.
View Article and Find Full Text PDFBackground: The retinal pigment epithelium (RPE) is implicated in the pathophysiology of many retinal degenerative diseases. This cell layer is also an ideal target for cell-based therapies. Several early phase clinical trials evaluating cell therapy approaches for diseases involving the RPE, such as age-related macular degeneration and Stargardt's macular dystrophy have been published.
View Article and Find Full Text PDFArticle Synopsis
- The purpose of the study was to assess the outcomes of eyes that developed endophthalmitis after intravitreal anti-vascular endothelial growth factor injections, specifically comparing treatments with and without microbiologic cultures.
- The study included 165 cases from July 2013 to September 2019, dividing them into two groups: one that received microbiologic sampling while treated with antibiotics and another that did not send samples for culture.
- Results showed that while there was a slight difference in visual acuity loss between the two groups at the 6-month follow-up, management without cultures may still be a viable strategy when microbiologic facilities are unavailable.
Purpose: To determine the relationship between stopper position and injection volume in aflibercept and ranibizumab prefilled syringes (PFS).
Methods: Empty aflibercept 2.0 mg PFS and ranibizumab 0.
Background/purpose: To identify geographic and socioeconomic variables predictive of residential proximity to retinopathy of prematurity (ROP) clinical trial locations.
Methods: This cross-sectional epidemiological study used census tract-level data from three national public data sets and trial-level data from ClinicalTrials.gov.
Unlabelled: To identify geographic and socioeconomic variables predictive of residential proximity to neovascular age-related macular degeneration (nAMD) clinical trial locations.
Design: Retrospective, cross-sectional study.
Methods: Census tract-level data from public datasets and trial-level data from ClinicalTrials.
Purpose: To assess visual acuity (VA) outcomes of epiretinal membrane (ERM) surgery following primary rhegmatogenous retinal detachment (RD) repair and to identify OCT features predictive of visual outcomes.
Design: Retrospective, consecutive case series.
Subjects: Eyes undergoing pars plana vitrectomy (PPV) with membrane peel (MP) surgery for ERM following primary RD repair (PPV with or without scleral buckle (SB) and gas tamponade).
Purpose Of Review: This review describes therapeutic research programs for geographic atrophy (GA) due to age-related macular degeneration (AMD). We highlight clinical trial data from phase I, II, and III studies.
Recent Findings: There are currently no treatments for GA, a form of advanced AMD that causes significant visual morbidity.
Purpose: We compared the ability of ophthalmologists to identify neovascularization (NV) in patients with proliferative diabetic retinopathy using swept-source optical coherence tomography angiography (SS-OCTA) and fluorescein angiography (FA).
Design: Retrospective study comparing diagnostic instruments.
Methods: Eyes with proliferative diabetic retinopathy or severe nonproliferative diabetic retinopathy and a high suspicion of NV based on clinical examination were imaged using SS-OCTA and FA at the same visit.
Purpose: We sought to investigate bacterial dispersion with patient face mask use during simulated intravitreal injections.
Design: Prospective cross-sectional study.
Methods: Fifteen healthy subjects were recruited for this single-center study.
Differences between target and implanted intraocular lens (IOL) power in Ethiopian cataract outreach campaigns were evaluated, and machine learning (ML) was applied to optimize the IOL inventory and minimize avoidable refractive error. Patients from Ethiopian cataract campaigns with available target and implanted IOL records were identified, and the diopter difference between the two was measured. Gradient descent (an ML algorithm) was used to generate an optimal IOL inventory, and we measured the models performance across varying surplus levels.
View Article and Find Full Text PDFPurpose: To characterize the rates of panretinal photocoagulation (PRP) and anti-vascular endothelial growth factor (VEGF) medications before and after publication of the Diabetic Retinopathy Clinical Research Network protocol S.
Design: A retrospective, cross-sectional study from January 2012, through September 2019, using a nationally representative claims-based database, Clinformatics Data Mart Database (OptumInsight, Eden Prairie, MN).
Participants: Eyes newly diagnosed with proliferative diabetic retinopathy (PDR), continuous enrollment, and no prior treatment with PRP or anti-VEGF agents.
Purpose: Widefield swept source optical coherence tomography angiography (WF SS-OCTA) imaging was compared with ultra-widefield (UWF) fluorescein angiography (FA) imaging to better understand changes in retinal nonperfusion before and after panretinal photocoagulation (PRP) in treatment-naïve eyes with proliferative diabetic retinopathy (PDR).
Design: Prospective, observational, consecutive case series.
Methods: Participants with treatment-naïve PDR were imaged using the SS-OCTA 12- × 12-mm scan pattern at baseline and at 1 week, 1 month, and 3 months after PRP.