Publications by authors named "John Haydek"
Background & Aims: This American Gastroenterological Association (AGA) living guideline is intended to support practitioners in the pharmacological management of moderate-to-severe ulcerative colitis (UC).
Methods: A multidisciplinary panel of content experts and guideline methodologists used the Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework to prioritize clinical questions, identify patient-centered outcomes, conduct an evidence synthesis, and develop recommendations on the pharmacological management of moderate-to-severe UC.
Results: The AGA guideline panel made 14 recommendations.
Introduction: Pouchitis and Crohn's-like disease of the pouch (CLDP) are common in patients who undergo ileal pouch anal anastomosis for ulcerative colitis. We conducted separate systematic reviews to evaluate the effectiveness of available interventions to prevent and treat pouchitis and CLDP.
Methods: Through systematic literature reviews, we identified studies that evaluated the effectiveness of probiotics, antibiotics, 5-aminosalicylates, nonsystemic oral corticosteroids, and advanced therapies for prevention and treatment of pouchitis and CLDP for meta-analysis.
Background & Aims: We performed an updated systematic review and network meta-analysis to inform the 2024 American Gastroenterological Association (AGA) Clinical Guidelines on the management of moderate-to-severe ulcerative colitis (UC).
Methods: We searched multiple electronic databases through November 21, 2023, to identify randomized controlled trials in adults with moderate-to-severe UC, comparing different advanced therapies (tumor necrosis factor antagonists, vedolizumab, sphingosine-1-phosphate receptor modulators, interleukin 12/23 or selective interleukin 23 antagonists, and Janus kinase [JAK] inhibitors) against placebo or another active comparator. Our primary outcomes were induction and maintenance of clinical remission, and our secondary outcome was endoscopic improvement.
Article Synopsis
- Pouchitis is a common issue after surgery for ulcerative colitis, and the AGA has developed guidelines to help doctors manage this condition effectively.
- A panel assessed clinical questions and outcomes to create 9 recommendations for treating pouchitis, Crohn's-like disease, and cuffitis.
- Key recommendations include using antibiotics for intermittent pouchitis, considering probiotics for prevention, and exploring advanced immunosuppressive therapies for chronic cases or those resistant to antibiotics.
Article Synopsis
- Resident conferences serve as key educational platforms for both trainees and faculty, with a focus on collaborative learning.
- Clinician-librarians have partnered with residency programs to create educational blogs that provide evidence-based insights based on real clinical questions discussed at these conferences.
- Over 2000 blog posts have been created in the last decade, attracting more than 1800 views each month, highlighting the blogs' effectiveness in promoting evidence-based practices and fostering interdisciplinary collaboration in medical education.
Editorial: infliximab or adalimumab as first- or second-line anti-TNF-conflicting evidence.
Aliment Pharmacol Ther
September 2021
Article Synopsis
- A study evaluated a non-endoscopic cell collection device for screening Barrett's esophagus (BE) in patients at risk, highlighting its potential as a less invasive alternative to traditional endoscopy.
- The device was successfully swallowed by 99.5% of participants, yielding a sample adequacy rate of 91%, with 84% of the samples rated as high quality.
- Most patients (93%) would be willing to repeat the procedure, and 65% preferred this method over the more invasive esophagogastroduodenoscopy (EGD).
Article Synopsis
- * The condition can stem from prescription medications, illicit drugs, or a combination of substances, leading to various clinical symptoms ranging from mild to severe.
- * A case study presents a 25-year-old woman with substance abuse issues, showing symptoms of serotonin syndrome complicated by takotsubo cardiomyopathy, highlighting the need for quick diagnosis and treatment to reduce risks.
Article Synopsis
- Medical knowledge is rapidly growing, and there's a need for future physicians to effectively navigate and utilize this information, prompting the authors to create an evidence-based medicine (EBM) course for students transitioning into residency.
- The elective course at Emory University engaged fourth-year medical students through interactive learning and independent work, equipping them with tools to critically analyze medical literature.
- Results showed a significant improvement in students' EBM knowledge and skills, indicating that the course successfully prepared them for practical, evidence-based learning in their medical careers.
Article Synopsis
- Sickle cell disease (SCD) increases the risk of hospitalizations and mortality, and the study focuses on a complication called sickle cell hepatopathy (SCH), specifically extreme hyperbilirubinemia (EH).
- The aim is to determine how EH affects morbidity and mortality in patients with SCD, using data from a retrospective cohort study at Grady Memorial Hospital.
- The study found that 4.8% of patients had severe EH, with significant differences in genotypes, revealing that those with hemoglobin SS are more likely to experience EH and higher liver enzyme levels.
Article Synopsis
- * In a study involving 251 adults treated with R-CHOP chemotherapy, 10% developed steatosis (fatty liver), mainly within the first 36 months post-treatment, with significant weight gain observed after treatment despite stable weights during chemotherapy.
- * Factors like higher baseline body mass index (BMI) and hyperlipidemia were associated with the development of steatosis, and etoposide-containing regimens were found to lead to faster onset of fatty liver compared
Article Synopsis
- Clinician educators recognize the importance of training medical students in teaching skills, but formal instruction and practice opportunities are limited.* -
- The Medical Student Teaching Competition (MSTC) was established at Emory University to engage students in teaching through mentorship and a competitive presentation format, leading to increased participation.* -
- Attendance at the MSTC event led to heightened interest among students in teaching and academic medicine, suggesting the potential for similar programs to enhance medical education across other institutions.*
Fecal microbiota transplant for Clostridium difficile infection in older adults.
Therap Adv Gastroenterol
May 2016
Background: The objective of this study was to describe the safety of fecal microbiota transplant (FMT) for Clostridium difficile infection (CDI) among older adults.
Methods: We performed a case review of all FMT recipients aged 65 or older treated at Emory University Hospital, a tertiary care and referral center for Georgia and surrounding states.
Results: CDI resolved in 27 (87%) of 31 respondents, including three individuals who received multiple FMTs.
Alkynoate synthesis through the vinylogous reactivity of rhodium(II) carbenoids.
Angew Chem Int Ed Engl
August 2012
Siloxy group migration: A rhodium(II) carbenoid approach has been developed for the synthesis of alkynoates. This transformation combines the addition of enol ethers at the vinylogous position of β-siloxy-substituted vinyldiazo derivatives with a siloxy group migration to give the products as single diastereomers.
View Article and Find Full Text PDFBackground: Photodynamic therapy (PDT) may be used to ablate high-grade dysplasia/early stage cancer (HGD/T1) in patients with Barrett's esophagus. PDT may result in esophageal stricture. This nonrandomized, unblinded, dose de-escalation study in consecutive patients was designed to determine the lowest light dose effective for ablation of HGD/T1 while reducing the incidence of stricture.
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