The wrinkle and its measurement--a skin surface Profilometric method.

This study outlines a simple 'Profilometric' method for measuring the size and function of the wrinkles. Wrinkle size was measured in relaxed conditions and the representative parameters were considered to be the mean 'Wrinkle Depth', the mean 'Wrinkle Area', the mean 'Wrinkle Volume', and the mean 'Wrinkle Tissue Reservoir Volume' (WTRV). These parameters were measured in the wrinkle profiles under relaxed conditions.

Hemorrhagic Kaposi sarcoma. Successful treatment with IFN-alpha.

A 76-year-old woman with atypical hemorrhagic Kaposi sarcoma is presented. The patient was treated with recombinant interferon alpha-2b (3,000,000 IU) subcutaneously, three times weekly for 6 months and twice weekly as maintenance dose for 14 months with excellent response and no recurrence after a 7 years of follow-up.

Amelanotic subungual malignant melanoma with multiple nodular local skin metastases.

We present a 72-year-old man with a subungual amelanotic malignant melanoma (MM) on the right first toe with numerous local nodular metastases after trauma and without regional lymph node involvement. Most of the lesions were angiomatous (reddish blue), and some had a hyperkeratotic surface, clinically resembling Kaposi sarcoma. Results of biopsies performed on skin taken from the toe and from a metastatic lesion of the tibia revealed a classic case of amelanotic MM.