Publications by authors named "John H J Yoo"
Demographic and pathologic factor regression to a growth rate model of p16-negative oral cavity squamous cell carcinoma.
Laryngoscope Investig Otolaryngol
October 2022
Objectives: The current study aims to quantify the growth rate of p16-negative oral cavity squamous cell carcinoma, characterize causative relationships between demographic risk factors and tumor growth, and examine pathologic findings associated with the tumor growth rate at a tertiary care institution. It is hypothesized that causative relationships will be drawn between the individual sociodemographic and pathologic factors and oral cavity p16-negative squamous cell carcinoma growth rate.
Methods: Prospectively recruited participants, receiving surgical intervention only, were followed from initial staging CT scan to surgical resection.
Article Synopsis
- Pleomorphic adenoma (PA) is the most frequently occurring benign tumor in salivary glands, and the study investigates the expression of Kallikrein-related peptidases (KLKs) as potential biomarkers in these tumors.
- Researchers analyzed fresh PA tissue from 26 specimens to assess KLK1-15 mRNA levels and corresponding protein expressions using advanced techniques, finding that KLK1, KLK12, and KLK13 were downregulated.
- The research is significant as it is the first to map KLK expression profiles in PA, highlighting potential areas for future clinical applications based on these findings.