Clinical Best Practices for Radiation Safety During Lutetium-177 Therapy.

Importance: 177 Lu therapy as part of theranostic treatment for cancer is expanding but it can be a challenge for sites with limited radiation protection staff to implement the radiation safety program required for therapeutic nuclear medicine.

Objective: To increase the adoption of 177 Lu therapy, especially in smaller centers and clinics, by providing a collection of radiation safety best practices and operational experience. To provide a resource for radiation safety officers supporting the implementation of a 177 Lu therapy program.

Node-Dependent Photoinduced Electron Transfer in Third-Generation 2D MOFs Containing Earth-Abundant Metal Ions.

Five isostructural 2D metal-organic frameworks (MOFs), based on a photoactive Cu metallolinker and mixed mono-/dinuclear secondary building units (SBUs), are reported. The MOFs (M = Mn, Co, Cu, Zn, and Cd) exhibit broad absorption across the visible-light spectrum and emission centered at ca. 730 nm.

Light-harvesting, 3rd generation Ru/Co MOF with a large, tubular channel aperture.

A photoactive, hetero-metallic CoII/RuII-based metal-organic framework (MOF) with a large channel aperture, ca. 21 Å, is reported. The photophysical properties of the MOF are derived from the RuII nodes giving rise to emission centred at ca.

Oxide-mediated recovery of field-effect mobility in plasma-treated MoS.

Precise tunability of electronic properties of two-dimensional (2D) nanomaterials is a key goal of current research in this field of materials science. Chemical modification of layered transition metal dichalcogenides leads to the creation of heterostructures of low-dimensional variants of these materials. In particular, the effect of oxygen-containing plasma treatment on molybdenum disulfide (MoS) has long been thought to be detrimental to the electrical performance of the material.

The risk of unintentional out-of-network encounters with hospital-based physicians at in-network hospitals.

Objective: When hospital-based specialists including emergency physicians, anesthesiologists, pathologists and radiologists are not included in the same insurance networks as their parent hospitals, it creates confusion and leads to unexpected costs for patients. This study explored the frequency with which hospital-based physicians at academic medical centers are not included in the network directories for the same insurance networks as their parent teaching hospitals.

Methods: We studied teaching hospitals with residency programs in all four hospital-based specialties.

Ag colloids and arrays for plasmonic non-radiative energy transfer from quantum dots to a quantum well.

Non-radiative energy transfer (NRET) can be an efficient process of benefit to many applications including photovoltaics, sensors, light emitting diodes and photodetectors. Combining the remarkable optical properties of quantum dots (QDs) with the electrical properties of quantum wells (QWs) allows for the formation of hybrid devices which can utilize NRET as a means of transferring absorbed optical energy from the QDs to the QW. Here we report on plasmon-enhanced NRET from semiconductor nanocrystal QDs to a QW.

Influence of plasmonic array geometry on energy transfer from a quantum well to a quantum dot layer.

A range of seven different Ag plasmonic arrays formed using nanostructures of varying shape, size and gap were fabricated using helium-ion lithography (HIL) on an InGaN/GaN quantum well (QW) substrate. The influence of the array geometry on plasmon-enhanced Förster resonance energy transfer (FRET) from a single InGaN QW to a ∼80 nm layer of CdSe/ZnS quantum dots (QDs) embedded in a poly(methyl methacrylate) (PMMA) matrix is investigated. It is shown that the energy transfer efficiency is strongly dependent on the array properties and an efficiency of ∼51% is observed for a nanoring array.

Uncooled CMOS terahertz imager using a metamaterial absorber and pn diode.

We demonstrate a low-cost uncooled terahertz (THz) imager fabricated in a standard 180 nm CMOS process. The imager is composed of a broadband THz metamaterial absorber coupled with a diode microbolometer sensor where the pn junction is used as a temperature sensitive device. The metamaterial absorber array is integrated in the top metallic layers of a six metal layer process allowing for complete monolithic integration of the metamaterial absorber and sensor.

Feedback network models for quantum transport.

Quantum feedback networks have been introduced in quantum optics as a framework for constructing arbitrary networks of quantum mechanical systems connected by unidirectional quantum optical fields, and has allowed for a system theoretic approach to open quantum optics systems. Our aim here is to establish a network theory for quantum transport systems where typically the mediating fields between systems are bidirectional. Mathematically, this leads us to study quantum feedback networks where fields arrive at ports in input-output pairs, making it a special case of the unidirectional theory where inputs and outputs are paired.

Non-abelian Weyl commutation relations and the series product of quantum stochastic evolutions.

We show that the series product, which serves as an algebraic rule for connecting state-based input-output systems, is intimately related to the Heisenberg group and the canonical commutation relations. The series product for quantum stochastic models then corresponds to a non-abelian generalization of the Weyl commutation relation. We show that the series product gives the general rule for combining the generators of quantum stochastic evolutions using a Lie-Trotter product formula.

On structure-preserving transformations of the Ito generator matrix for model reduction of quantum feedback networks.

Two standard operations of model reduction for quantum feedback networks, elimination of internal connections under the instantaneous feedback limit and adiabatic elimination of fast degrees of freedom, are cast as structure-preserving transformations of Itō generator matrices. It is shown that the order in which they are applied is inconsequential.

Single photon quantum filtering using non-Markovian embeddings.

We determine quantum master and filter equations for continuous measurement of systems coupled to input fields in certain non-classical continuous-mode states, specifically single photon states. The quantum filters are shown to be derivable from an embedding into a larger non-Markovian system, and are given by a system of coupled stochastic differential equations.

Principles and applications of quantum control engineering.

This is a brief survey of quantum feedback control and specifically follows on from the two-day conference Principles and applications of quantum control engineering, which took place in the Kavli Royal Society International Centre at Chicheley Hall, on 12-13 December 2011. This was the eighth in a series of principles and applications of control to quantum systems workshops.

Can peak expiratory flow measurements differentiate chronic obstructive pulmonary disease from congestive heart failure?

Dyspneic patients are commonly encountered by Emergency Medical Service (EMS). Frequent causes include Chronic Obstructive Pulmonary Disease (COPD) and Congestive Heart Failure (CHF). Measurement of peak expiratory flow rate (PEFR) has been proposed to help differentiate COPD from CHF.

Antibody to parvovirus B19 nonstructural protein is associated with chronic arthralgia in patients with chronic fatigue syndrome/myalgic encephalomyelitis.

Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a neuro-immune disease of uncertain pathogenesis. Human parvovirus B19 infection has been shown to occur just prior to development of the onset of CFS/ME in several cases, although B19 seroprevalence studies do not show any significant differences between CFS/ME and controls. In this study, we analysed parvovirus B19 markers in CFS/ME patients (n=200), diagnosed according to Fukuda CDC criteria, and normal blood donors (n=200).

Microbial infections in eight genomic subtypes of chronic fatigue syndrome/myalgic encephalomyelitis.

Background: The authors have previously reported genomic subtypes of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) based on expression of 88 human genes.

Aim: To attempt to reproduce these findings, determine the specificity of this signature to CFS/ME, and test for associations between CFS/ME subtype and infection.

Methods: Expression levels of 88 human genes were determined in blood of 62 new patients with idiopathic CFS/ME (according to Fukuda criteria), six patients with Q-fever-associated CFS/ME from the Birmingham Q-fever outbreak (according to Fukuda criteria), 14 patients with endogenous depression (according to DSM-IV criteria) and 29 normal blood donors.

Parathyroid adenoma radiation dose simulator.

Introduction: As the number of radioisotope localization cases increased at our facility, the pathologists expressed concern regarding radiation exposure from parathyroid specimens. The radiation safety officer was consulted to analyze personnel radiation protection issues.

Methods: Analysis of simulated specimens was performed for a range of activities and masses corresponding to the values that have been observed.

Recombinant TSH-stimulated, radioguided differentiated thyroid carcinoma surgery.

A novel approach to locating and surgically resecting occult metastatic foci in a 25-year-old female with a history of total thyroidectomy for differentiated thyroid carcinoma was attempted. Two iodine-131 (131I) body scans were performed: one after the patient underwent a 2-3 week thyroxine withdrawal, and another the following week utilizing recombinant TSH-stimulation. Then the patient was treated with 151 mCi of 131I, and 2 weeks later, without further hormonal manipulation, she had radioguided surgery.