Label free detection of CD4+ and CD8+ T cells using the optofluidic ring resonator.

We have demonstrated label free detection of CD4+ and CD8+ T-Lymphocyte whole cells and CD4+ T-Lymphocyte cell lysis using the optofluidic ring resonator (OFRR) sensor. The OFRR sensing platform incorporates microfluidics and photonics in a setup that utilizes small sample volume and achieves a fast detection time. In this work, white blood cells were isolated from healthy blood and the concentrations were adjusted to match T-Lymphocyte levels of individuals infected with HIV.

Versatile waveguide-coupled optofluidic devices based on liquid core optical ring resonators.

A versatile waveguide-coupled optofluidic device using the liquid core optical ring resonator (LCORR) that can be operated with liquid of any refractive index (RI) is theoretically analyzed and experimentally demonstrated. The results confirm the confinement of resonant modes for all sample RIs, and reveal that confined modes in a high-RI core are excited by an external waveguide by resonant tunneling through the LCORR wall. It is further found that a thin wall must be used for effective interaction between the core mode and the waveguide.

SERS-based detection in an optofluidic ring resonator platform.

The development of surface enhanced Raman scattering (SERS) detection has made Raman spectroscopy relevant for highly sensitive labon- a-chip bio/chemical sensors. Despite the tremendous benefit in specificity that a Raman-based sensor can deliver, development of a lab-on-a- chip SERS tool has been limited thus far. In this work, we utilize an optofluidic ring resonator (OFRR) platform to develop a SERS-based detection tool with integrated microfluidics.