Contrast-enhanced magnetic resonance urography at 3T: clinical feasibility.

Objective: The objective of this study was to assess the feasibility of performing diagnostic-quality contrast-enhanced excretory magnetic resonance urography (eMRU) at 3T, examining both image quality and diagnostic accuracy for a range of urinary tract abnormalities.

Methods: The diuretic-enhanced 3T eMRUs of 37 patients were reviewed to assess for the diagnostic conspicuity of urinary tract abnormalities, extent of urinary tract visualization on excretory images, and presence and severity of image artifacts.

Results: Excretory images allowed greater than 75% visualization in 90.

MRI of pregnancy-related issues: abnormal placentation.

Objective: In this article, we review the clinical significance of abnormal placentation and the role of MRI in diagnosis and management of this potentially morbid condition. We present our clinical perspective on diagnosing this challenging problem with MRI and review the imaging findings that can lead to a correct diagnosis.

Conclusion: As abnormal placentation becomes more prevalent, in large part due to the markedly rising rates of cesarean delivery, there is a need for accurate antenatal diagnosis of this condition to prevent maternal morbidity and mortality.

Magnetic resonance urography.

Excellent contrast resolution and lack of ionizing radiation make magnetic resonance urography (MRU) a promising technique for noninvasively evaluating the entire urinary tract. While MRU currently lags behind CT urography (CTU) in spatial resolution and efficiency, new hardware and sequence developments have contributed to a resurgence of interest in MRU techniques. By combining unenhanced sequences with multiphase contrast-enhanced and excretory phase imaging, a comprehensive assessment of the kidneys, ureters, bladder, and surrounding structures is possible with image quality rivaling that obtained with other techniques.

Acceleration of autoimmunity by organochlorine pesticides in (NZB x NZW)F1 mice.

Systemic lupus erythematosus (SLE) is an autoimmune disorder that affects women more frequently than men. In the (NZB times NZW)F1 mouse, a murine SLE model, the presence or absence of estrogen markedly influences the rate of progression of disease. Three organochlorine pesticides with estrogenic effects were administered chronically to ovariectomized female (NZB times NZW)F1 mice, and we measured the time to development of renal disease, the principal clinical manifestation of lupus in this model.