Publications by authors named "John Galic"
Objective: To compare the prevalence of angle closure in eyes with retinal vein occlusion (RVO) with control eyes and assess the possible association between angle-closure and RVO.
Patients And Methods: This prospective, blinded case-control study included patients with a history of RVO (cases) and control individuals matched for age and refractive error. Clinical characteristics and angle-based structures derived from anterior-segment optical coherence tomography (AS-OCT) were analyzed.
Purpose: To assess the real-world efficacy and safety of aflibercept for the treatment of diabetic macular edema (DME).
Methods: A systematic search was conducted across multiple databases. Articles were included if participants had DME and received aflibercept treatment for a minimum of 52 ± 4 weeks.
Purpose. To describe the histopathological features of vitreous samples obtained after vitrectomy surgery from diabetic and nondiabetic patients. Methods.
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- Diabetic retinopathy (DR) is a significant cause of blindness in working-age adults, with early signs including the loss of pericytes, a type of cell supporting blood vessels.
- This study analyzed vitreous samples from 125 diabetic and nondiabetic patients to assess pericyte presence, using a scoring system to quantify loss.
- Results showed that all nondiabetic samples had no pericyte loss, while diabetic patients exhibited varying degrees of loss, indicating a strong link between pericyte loss and blood sugar levels, suggesting that vitreous samples could provide valuable insights for managing diabetes.
Purpose: A review of treat-and-extend regimens (TERs) with intravitreal anti-vascular endothelial growth factor agents in retinal diseases.
Methods: There is a lack of consensus on the definition and optimal application of TER in clinical practice. This article describes the supporting evidence and subsequent development of a generic algorithm for TER dosing with anti-vascular endothelial growth factor agents, considering factors such as criteria for extension.
Retinoblastoma (RB) is extremely rare in adults. We describe a case of RB diagnosed by cytology in a vitrectomy specimen of a 23-year-old patient who presented with diminished visual acuity and retinal detachment in the absence of a clinically-visible mass. Cytological examination of the vitreous fluid showed clusters of loosely cohesive atypical cells with high nuclear to cytoplasmic ratio and "salt and pepper" chromatin pattern in a background of normal neuronal retinal cells.
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