Pandemic (H1N1) 2009 influenza in NSW: an overview of the public health response.

In April 2009, a new influenza A virus, pandemic (H1N1) 2009 influenza, was identified in Mexico and the United States of America. The NSW response was co-ordinated by the Public Health Emergency Operations Centre through an incident control structure that included planning, operations and logistics teams with designated roles and responsibilities for the public health response. The emphasis of public health action changed as the pandemic moved through three response phases: DELAY, CONTAIN and PROTECT.

Dimerization and isomerization reactions of alpha-lithiated terminal aziridines.

The scope of dimerization and isomerization reactions of alpha-lithiated terminal aziridines is detailed. Regio- and stereoselective deprotonation of simple terminal aziridines with lithium 2,2,6,6-tetramethylpiperidide (LTMP) or lithium dicyclohexylamide (LiNCy2) generates trans-alpha-lithiated terminal aziridines. These latter species can then undergo dimerization or isomerization reactions depending on the nature of the N-protecting group.

Intramolecular cyclopropanation of unsaturated terminal aziridines.

Regio- and stereoselective deprotonation of bishomoallylic terminal N-Bus (Bus=tert-butylsulfonyl)-protected aziridines generate aziridinyl anions that undergo diastereoselective intramolecular cyclopropanation giving trans-2-aminobicyclo[3.1.0]hexanes in good to excellent yields.

Substituted aziridines by lithiation-electrophile trapping of terminal aziridines.

[reaction: see text] Regio- and stereoselective deprotonation of N-Bus (Bus = tert-butylsulfonyl)-protected terminal aziridines with lithium 2,2,6,6-tetramethylpiperidide generates a nonstabilized (H-substituted) aziridinyl anion that undergoes in situ or external electrophile trapping under experimentally straightforward conditions to give trans-disubstituted aziridines in good to excellent yields.