Publications by authors named "John Frith"
Background: In patients with humoral immunodeficiency, the progression of bronchiectasis has been known to occur despite adequate gammaglobulin therapy and in the absence of recurrent infections. This observation suggests that factors other than gammaglobulin replacement might play a part in the prevention of lung damage in this population. α-Antitrypsin deficiency can be associated with bronchiectasis, a chronic inflammatory lung disease.
View Article and Find Full Text PDFCold urticaria and cholinergic urticaria are two distinct entities. The presentation of exclusive cold-induced cholinergic urticaria is very rare. The patient described herein had experienced urticaria in the exclusive setting of exercising in a cold environment.
View Article and Find Full Text PDFIdiopathic pancreatitis in a patient with a STAT3 mutation.
Allergy Rhinol (Providence)
January 2016
Article Synopsis
- Hyperimmunoglobulin E syndrome (HIES) is a rare immune disorder causing severe skin and respiratory infections and involves high levels of immunoglobulin E.
- A patient with a known STAT3 deficiency related to HIES had extraimmune symptoms like unique facial features, skeletal fractures, and episodes of pancreatitis.
- Research indicates that STAT3 plays a crucial role in pancreatic health, and while mouse studies show STAT3 mutations worsen pancreatitis, the link in humans has not been fully established until this case was reported.
Objective: To improve general practitioners' knowledge and skills about diabetic retinopathy.
Setting: An upskilling program of 11 Sydney (New South Wales) GPs.
Main Outcome Measures: Level of competency determined by an educational assessment before and six weeks after the program.