FishShapes v1: Functionally relevant measurements of teleost shape and size on three dimensions.

Teleost fishes account for 96% of all fish species and exhibit a spectacular variety of body forms. Teleost lineages range from deep bodied to elongate (e.g.

A survey of retaining faculty at a new medical school: opportunities, challenges and solutions.

Background: At well-established academic university settings, retaining faculty remains a pressing challenge due to competing market forces, decreasing institutional support, and changing personal expectations. There is a paucity of information about the difficulties faced by new medical schools to maintain their academic workforce. The objective of this study was to determine the challenges facing the faculty at a newly developed medical school.

Curriculum mapping as a tool to facilitate curriculum development: a new School of Medicine experience.

Background: Every curriculum needs to be reviewed, implemented and evaluated; it must also comply with the regulatory standards. This report demonstrates the value of curriculum mapping (CM), which shows the spatial relationships of a curriculum, in developing and managing an integrated medical curriculum.

Methods: A new medical school developed a clinical presentation driven integrated curriculum that incorporates the active-learning pedagogical practices of many educational institutions worldwide while adhering to the mandated requirements of the accreditation bodies.

Prepubertal children exposed to concentrated disadvantage: An exploratory analysis of inflammation and metabolic dysfunction.

Objective: It is unclear whether physiologic and metabolic biomarkers are associated with chronic stressors evidenced during early childhood.

Methods: Cross-sectional data were obtained from a cohort of healthy, prepubertal (Tanner stage < 2) children (n = 96; age: 8.06 [7.

Identification of speckle-type POZ protein somatic mutations in African American prostate cancer.

The speckle-type POZ protein (SPOP) is a tumor suppressor in prostate cancer (PCa). SPOP somatic mutations have been reported in up to 15% of PCa of those of European descent. However, the genetic roles of SPOP in African American (AA)-PCa are currently unknown.

Falls in HIV-infected patients: a geriatric syndrome in a susceptible population.

Background: Falls is a common geriatric syndrome that has not been well characterized in HIV-infected populations.

Methods: We retrospectively reviewed our database and identified patients who fell over the last 12 months.

Results: Thirty-two patients were identified (incidence rate of 16 × 1000 patients per year).

Polycyclic aromatic hydrocarbons-induced ROS accumulation enhances mutagenic potential of T-antigen from human polyomavirus JC.

Polycyclic aromatic hydrocarbons (PAHs) are the products of incomplete combustion of organic materials, which are present in cigarette smoke, deep-fried food, and in natural crude oil. Since PAH-metabolites form DNA adducts and cause oxidative DNA damage, we asked if these environmental carcinogens could affect transforming potential of the human Polyomavirus JC oncoprotein, T-antigen (JCV T-antigen). We extracted DMSO soluble PAHs from Deepwater Horizon oil spill in the Gulf of Mexico (oil-PAHs), and detected several carcinogenic PAHs.

Non-AIDS-defining cancers in New Orleans.

Background: Non-AIDS-defining cancers in HIV-infected patients in the highly active antiretroviral therapy era have increased. To our knowledge a comprehensive review of non-AIDS-related malignancies in New Orleans has not yet been conducted.

Methods: Databases from main institutions in New Orleans were queried retrospectively for the years 2001 to 2011.

[Competency-based training and work world: from grading to employability].

Considered as an element of business discourse, the competence-based education emerges associated with processes of productive restructuring influencing the economy since 1970. These processes arise as a consequence of the crisis of the accumulation model based on mass production and consumption following the principles of taylorism and fordism. In the last decades, the State has been unable to solve the periodic crisis that afflicts late capitalism.

Differences in outcomes between elderly and nonelderly breast cancer patients in Louisiana.

Introduction: Elderly breast cancer patients are diagnosed with a higher stage of disease. They are also found to undergo less surgery, receive more frequently hormonal treatment and have decreased relative survival. The interest of this study was to examine the differences in treatment and survival between elderly versus young (>65 versus <65) patients in Louisiana.

Management of elderly and frail elderly cancer patients: the importance of comprehensive geriatrics assessment and the need for guidelines.

Objectives: Management of elderly and frail patients with cancer is complex and requires a multidisciplinary approach. This article reviews and discusses the current literature that evaluates the relevance of comprehensive geriatrics assessment (CGA) and other evaluation tools in the detection of this vulnerable patient population.

Methods: A literature search of articles in English, Spanish and Portuguese was conducted in PubMed through September 2011.

Fenofibrate-induced nuclear translocation of FoxO3A triggers Bim-mediated apoptosis in glioblastoma cells in vitro.

Anti-neoplastic potential of calorie restriction or ligand-induced activation of peroxisome proliferator activated receptors (PPARs) has been demonstrated in multiple studies; however, mechanism(s) by which tumor cells respond to these stimuli remain to be elucidated. One of the potent agonists of PPARα, fenofibrate, is a commonly used lipid-lowering drug with low systemic toxicity. Fenofibrate-induced PPARα transcriptional activity is expected to shift energy metabolism from glycolysis to fatty acid β-oxidation, which in the long-term, could target weak metabolic points of glycolysis-dependent glioblastoma cells.

Aberrant DNA methylation and prostate cancer.

Prostate cancer (PCa) is the most prevalent cancer, a significant contributor to morbidity and a leading cause of cancer-related death in men in Western industrialized countries. In contrast to genetic changes that vary among individual cases, somatic epigenetic alterations are early and highly consistent events. Epigenetics encompasses several different phenomena, such as DNA methylation, histone modifications, RNA interference, and genomic imprinting.

The clinical skills laboratory: a cost-effective venue for teaching clinical skills to third-year medical students.

The authors taught clinical examination and procedural skills using manikins in a clinical skills laboratory as a part of an integrated curriculum in the third-year clerk-ship. This teaching modality was effective and well received by students and faculty.