Publications by authors named "John Emmanuel Markantonis"
J Clin Apher
December 2023
Article Synopsis
- Sickle cell disease patients with a history of stroke are generally advised to maintain a hemoglobin S (HbS) level below 30% to prevent strokes, but a new chronic exchange protocol by UT Southwestern allows for a higher target of below 50% for low-risk patients.
- A retrospective study reviewed medical records of 49 patients over 10 years, finding that 33 maintained an average HbS level of 35.4% without any strokes or transient ischemic attacks linked to this higher target.
- The results suggest that relaxing the HbS target may provide a flexible treatment option for certain patients without increasing stroke risk, although further research is needed to confirm these findings.
