Advances in applied homeostatic modelling of the relationship between thyrotropin and free thyroxine.

Introduction: The relationship between pituitary TSH and thyroid hormones is central to our understanding of thyroid physiology and thyroid function testing. Here, we generated distribution patterns by using validated tools of thyroid modelling.

Methods: We simulated patterns of individual set points under various conditions, based on a homeostatic model of thyroid feedback control.