Publications by John Edgar Fontecha

Publications by authors named "John Edgar Fontecha"

Cardiovasc Toxicol

August 2022

Cardiac troponin T (TNNT2) is crucial for heart muscle contraction, with its splicing regulated by DYRK1A and SRSF6.
Altered splicing of TNNT2 is linked to heart failure, and this study explores how DYRK1A affects TNNT2 variants in stem cell-derived heart cells.
Findings show that increased DYRK1A boosts fetal TNNT2 variants and reduces adult ones while influencing the cell's response to the drug daunorubicin (DAU), particularly in how it affects heart beating frequency.

- John Edgar Fontecha's recent research primarily investigates the role of DYRK1A in the alternative splicing of TNNT2, a gene crucial for muscle contraction in cardiomyocytes.
- The study highlights how DYRK1A affects the phosphorylation of the splicing factor SRSF6, which in turn influences the formation of different transcript variants of TNNT2 with varying calcium sensitivities.
- Findings suggest that alterations in DYRK1A expression may impact daunorubicin toxicity in human induced pluripotent stem cell (iPSC)-derived cardiomyocytes, indicating potential therapeutic implications for cardiac treatments.