Publications by authors named "John E Yerg"
Multiple gene expression alterations have been linked to Alzheimer's disease (AD), implicating multiple metabolic pathways in its pathogenesis. However, a clear distinction between AD-specific gene expression changes and those resulting from nonspecific responses to toxic aggregating proteins has not been made. We investigated alterations in gene expression induced by human beta-amyloid peptide (Aβ) in a Caenorhabditis elegans AD model.
View Article and Find Full Text PDFQuantitative trait Loci specifying the response of body temperature to dietary restriction.
J Gerontol A Biol Sci Med Sci
February 2004
Article Synopsis
- Dietary restriction (DR) has been shown to slow down aging and increase lifespan in various species, with a notable impact on reducing body temperature in homeotherms like mice.
- A study conducted on genetically diverse mice revealed that about 35% of the variation in body temperature response to DR is influenced by genetics, with specific genetic regions identified on chromosomes 9 and 17.
- These findings suggest that the identified genetic factors could help further investigate how body temperature responses to DR might relate to life extension, and offer a pathway for discovering the underlying genes through positional cloning.
Article Synopsis
- - Dietary restriction (DR) can slow aging and increase lifespan in mammals by lowering body temperature (T(b)), suggesting T(b) could be linked to the benefits of DR.
- - A study on 28 strains of female mice found significant differences in T(b) responses to DR, with variations from 1.5 to 5 degrees Celsius below normal.
- - The observed T(b) variations were not connected to factors like thermoregulation or food intake, indicating potential for further research on the relationship between T(b) and life extension during DR.