Publications by authors named "John E Shalkham"
Objective: To establish cytomorphologic criteria that might facilitate the identification of malignant melanoma (MM) cells with epithelioid (nevoid) morphology, in fine needle aspiration biopsy material from the liver.
Study Design: Aspirated material from 18 cases of MM with epithelioid features and 24 cases of benign liver lesions (BLL) were examined. The cases were selected based on the availability of corresponding tissue biopsies, adequate cell block material or sufficient number of direct smears to perform immunocytochemical staining.
The Wisconsin State Laboratory of Hygiene's Cytology Program has contributed to the success of the Pap smear in substantially decreasing the number of cervical cancers in the United States. In addition to providing testing services to the Cervical Cancer Control Program of Wisconsin, the Department of Health and Family Services, and Planned Parenthood of Wisconsin, the Wisconsin State Laboratory of Hygiene (WSLH) maintains one of the largest schools of cytotechnology in the United States, which helps train individuals into a profession experiencing severe shortages. The Cytology Program has actively evaluated the new liquid-based testing technology to provide data to improve laboratory performance.
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- The study examined the clinical significance of rare atypical squamous cells of undetermined significance (ASCUS) in cervical screenings with 748 cases involved.
- When comparing rare ASCUS cases to normal limits and other abnormal cases, the risk of an abnormal result was found to be greater in the rare ASCUS group, but still less than in more definite abnormal cases.
- The findings suggested that while rare ASCUS raises the likelihood of abnormal results in conventional smears, it does not predict significant dysplasia and shows no clinical relevance in ThinPrep samples.