Publications by authors named "John E Desantis"
Article Synopsis
- The study investigates the immune receptor (IR) features of diffuse intrinsic pontine glioma (DIPG), a common and aggressive childhood brain tumor, utilizing advanced biopsy techniques and RNA sequencing.
- Researchers found that progressive DIPG samples showed higher immunoglobulin gene expression and fewer bacterial sequences compared to initial samples, suggesting changes in immune response.
- The analysis also revealed significant links between the presence of specific bacteria and potential survival outcomes, highlighting the importance of genomic studies in understanding DIPG and its immune interactions.
Bacteremia poses great risk for morbidity and mortality for immunocompromised cancer patients. Although the presence of bacteria within solid tumors is gaining greater attention, few studies have analyzed species of bacteria in the blood and their effect on cancer clinical outcomes. Using the Kraken 2 taxonomic profiling tool, we classified bacteria present in blood and primary tumors of cervical cancer and melanoma cases.
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