Mapping Relevance of Digital Measures to Meaningful Symptoms and Impacts in Early Parkinson's Disease.

Background: Adoption of new digital measures for clinical trials and practice has been hindered by lack of actionable qualitative data demonstrating relevance of these metrics to people with Parkinson's disease.

Objective: This study evaluated of relevance of WATCH-PD digital measures to monitoring meaningful symptoms and impacts of early Parkinson's disease from the patient perspective.

Methods: Participants with early Parkinson's disease (N = 40) completed surveys and 1:1 online-interviews.

Relative Meaningfulness and Impacts of Symptoms in People with Early-Stage Parkinson's Disease.

Background: Patient perspectives on meaningful symptoms and impacts in early Parkinson's disease (PD) are lacking and are urgently needed to clarify priority areas for monitoring, management, and new therapies.

Objective: To examine experiences of people with early-stage PD, systematically describe meaningful symptoms and impacts, and determine which are most bothersome or important.

Methods: Forty adults with early PD who participated in a study evaluating smartwatch and smartphone digital measures (WATCH-PD study) completed online interviews with symptom mapping to hierarchically delineate symptoms and impacts of disease from "Most bothersome" to "Not present," and to identify which of these were viewed as most important and why.

First use of high-frequency intensity modulation of narrow-linewidth laser light and its application in determination of 206,205,204Fr ground-state properties.

Collinear laser spectroscopy was performed on the nuclear ground states of the neutron-deficient isotopes (206,205,204)Fr. A new technique was developed to suppress hyperfine pumping in collinear laser spectroscopy of atoms. This involved high-frequency intensity modulation of narrow-linewidth laser light using fast-switching electro-optical modulators.