The Golden Age of Thermally Activated Delayed Fluorescence Materials: Design and Exploitation.

Since the seminal report by Adachi and co-workers in 2012, there has been a veritable explosion of interest in the design of thermally activated delayed fluorescence (TADF) compounds, particularly as emitters for organic light-emitting diodes (OLEDs). With rapid advancements and innovation in materials design, the efficiencies of TADF OLEDs for each of the primary color points as well as for white devices now rival those of state-of-the-art phosphorescent emitters. Beyond electroluminescent devices, TADF compounds have also found increasing utility and applications in numerous related fields, from photocatalysis, to sensing, to imaging and beyond.

MR-TADF liquid crystals: towards self assembling host-guest mixtures showing narrowband emission from the mesophase.

Creating (room temperature) liquid crystalline TADF materials that retain the photophysical properties of the monomolecular TADF emitters remains a formidable challenge. The strong intramolecular interactions required for formation of a liquid crystal usually adversely affect the photophysical properties and balancing them is not yet possible. In this work, we present a novel host-guest approach enabling unperturbed, narrowband emission from an MR-TADF emissive core from strongly aggregated columnar hexagonal (Col) liquid crystals.

Molecular asymmetry and rigidification as strategies to activate and enhance thermally activated delayed fluorescence in deep-blue MR-TADF emitters.

Two novel deep-blue multi-resonance thermally activated delayed fluorescence (MR-TADF) emitters, 1B-CzCrs and 2B-CzCrs, containing a fused carbazole unit were synthesized. The carbazole contributed to the emergence of TADF in these small molecules. Particularly, organic light-emitting diodes with 1B-CzCrs doped in the mCP host achieve a maximum external quantum efficiency of 12.

Oxidative Stress and Inflammation in Hepatic Diseases: Therapeutic Possibilities of N-Acetylcysteine.

Liver disease is highly prevalent in the world. Oxidative stress (OS) and inflammation are the most important pathogenetic events in liver diseases, regardless the different etiology and natural course. N-acetyl-l-cysteine (the active form) (NAC) is being studied in diseases characterized by increased OS or decreased glutathione (GSH) level.

Choline and Cystine Deficient Diets in Animal Models with Hepatocellular Injury: Evaluation of Oxidative Stress and Expression of RAGE, TNF-α, and IL-1β.

This study aims to evaluate the effects of diets deficient in choline and/or cystine on hepatocellular injury in animal models (young male Wistar rats, aged 21 days), by monitoring some of the oxidative stress biomarkers and the expression of RAGE, TNF-α, and IL-1β. The animals were divided into 6 groups (n = 10) and submitted to different diets over 30 days: AIN-93 diet (standard, St), AIN-93 choline deficient (CD) diet and AIN-93 choline and cystine deficient (CCD) diet, in the pellet (pl) and powder (pw) diet forms. Independently of the diet form, AIN-93 diet already led to hepatic steatosis and CD/CCD diets provoked hepatic damage.

Radiologic findings of segmental testicular infarction.

Objective: Our objective was to describe the radiologic findings of segmental testicular infarction and to establish a proper diagnosis that can avoid orchiectomy.

Conclusion: The presence of a triangular-shaped avascular intratesticular lesion on sonography or MRI and enhancement of the surrounding borders on enhanced MR images may suggest a presurgical diagnosis of segmental testicular infarction and therefore avoid a total orchiectomy in these patients.

Mucinous urothelial-type adenocarcinoma of the prostate.

A case of mucinous urothelial-type adenocarcinoma of the prostate in a 68-year-old man is reported. This is a rare neoplasm which probably originates from the proximal prostatic ducts or the prostatic urethra. This tumor does not express prostate-specific antigen, in contrast to the more common mucinous adenocarcinoma of the prostate, and may be misdiagnosed as a secondary, mainly colorectal, tumor.