MBD + C: How to Incorporate Metallic Character into Atom-Based Dispersion Energy Schemes.

The dispersion component of the van der Waals interaction in low-dimensional metals is known to exhibit anomalous "Type-C non-additivity" [ 1157]. This causes dispersion energy behavior at asymptotically large separations that is missed by popular atom-based schemes for dispersion energy calculations. For example, the dispersion interaction energy between parallel metallic nanotubes at separation falls off asymptotically as approximately , whereas current atom-based schemes predict asymptotically.

A Cadaveric Evaluation of Hypertrophic Obstructive Cardiomyopathy.

Hypertrophic obstructive cardiomyopathy (HOCM) describes a pathologic state in which the subaortic region of the interventricular septum undergoes significant hypertrophy and fibrosis, resulting in septal bowing into the left ventricle. The reduced left ventricular chamber size and altered cardiac function impair diastolic filling, stroke volume, and cardiac output. This case report evaluates the cardiac tissue of a 36-year-old, formalin-embalmed cadaver affected by HOCM, with the goal of providing a comprehensive overview of the gross and pathologic findings associated with the condition.

DFT exchange: sharing perspectives on the workhorse of quantum chemistry and materials science.

In this paper, the history, present status, and future of density-functional theory (DFT) is informally reviewed and discussed by 70 workers in the field, including molecular scientists, materials scientists, method developers and practitioners. The format of the paper is that of a roundtable discussion, in which the participants express and exchange views on DFT in the form of 302 individual contributions, formulated as responses to a preset list of 26 questions. Supported by a bibliography of 777 entries, the paper represents a broad snapshot of DFT, anno 2022.

Exact Sum-Rule Approach to Polarizability and Asymptotic van der Waals Functionals─Derivation of Exact Single-Particle Benchmarks.

Using a sum-rule approach, we develop an exact theoretical framework for polarizability and asymptotic van der Waals correlation energy functionals of small isolated objects. The functionals require only monomer ground-state properties as input. Functional evaluation proceeds via solution of a single position-space differential equation, without the usual summations over excited states or frequency integrations.

National Resident Matching Program Performance Among US MD and DO Seniors in the Early Single Accreditation Graduate Medical Education Era.

Introduction: As of the 2020 National Resident Matching Program (NRMP), nearly all applicants are evaluated together for graduate medical education (GME) candidacy. We set out to characterize US MD and DO Senior residency match performance in the single-accreditation GME era.

Methods: A retrospective study was conducted in 2021 utilizing data collected from the 2018 and 2020 NRMP Charting Outcomes in the Match publications aggregated and subdivided into three groups based on competitiveness: low (LC), moderate (MC), and high (HC).

Selected Cardiovascular and Psychological Changes Throughout a Competitive Season in Collegiate Female Swimmers.

Dobson, J, Harris, B, Claytor, A, Stroud, L, Berg, L, and Chrysosferidis, P. Selected cardiovascular and psychological changes throughout a competitive season in collegiate female swimmers. J Strength Cond Res 34(11): 3062-3069, 2020-Measures that reflect the balance between training-induced fatigue and recovery can provide valuable feedback to help revise training plans.

The contribution of small and large sensory afferents to postural control in patients with peripheral neuropathy.

Peripheral neuropathy (PN) is a multifarious disorder that is caused by damage to the peripheral nerves. Although the symptoms of PN vary with the etiology, most cases are characterized by impaired tactile and proprioceptive sensation that progresses in a distal to proximal manner. Balance also tends to deteriorate as the disorder becomes more severe, and those afflicted are substantially more likely to fall while walking compared with those who are healthy.

The Effects of Beetroot Juice on VOmax and Blood Pressure during Submaximal Exercise.

Beetroot juice (BR) has been shown to reduce blood pressure (BP) at rest and improve several performance parameters during exercise. However, the effect of BR on BP during submaximal exercise has not been investigated and its effects on VOmax are inconclusive. The purpose of this study was to investigate the effects of BR on VOmax and BP during submaximal exercise.

Retrieval practice and judgements of learning enhance transfer of physiology information.

It is well-documented that retrieval practice enhances the recall of simple and complex information (Karpicke and Aue in Educ Psychol Rev 27(2):317-326, 2015). Evidence is also accumulating that retrieval practice can enhance other cognitive processes such as the ability to critically evaluate research articles (Dobson et al. in Med Educ 52(5):513-525, 2018) and transfer of learning (Butler in J Exp Psychol Learn Mem Cogn 36(5):1118, 2010).

Anatomic and Histological Study of the Anterolateral Aspect of the Knee: A SANTI Group Investigation.

Background: The structure and function of the anterolateral aspect of the knee have been significantly debated, with renewed interest in this topic since the description of the anterolateral ligament (ALL).

Purpose: To define and describe the distinct structures of the lateral knee and to correlate the macroscopic and histologic anatomic features.

Study Design: Descriptive laboratory study.

Faraday cage screening reveals intrinsic aspects of the van der Waals attraction.

General properties of the recently observed screening of the van der Waals (vdW) attraction between a silica substrate and silica tip by insertion of graphene are predicted using basic theory and first-principles calculations. Results are then focused on possible practical applications, as well as an understanding of the nature of vdW attraction, considering recent discoveries showing it competing against covalent and ionic bonding. The traditional view of the vdW attraction as arising from pairwise-additive London dispersion forces is considered using Grimme's "D3" method, comparing results to those from Tkatchenko's more general many-body dispersion (MBD) approach, all interpreted in terms of Dobson's general dispersion framework.

Retrieval practice enhances the ability to evaluate complex physiology information.

Objective: Many investigations have shown that retrieval practice enhances the recall of different types of information, including both medical and physiological, but the effects of the strategy on higher-order thinking, such as evaluation, are less clear. The primary aim of this study was to compare how effectively retrieval practice and repeated studying (i.e.

Using extensional flow to reveal diverse aggregation landscapes for three IgG1 molecules.

Monoclonal antibodies (mAbs) currently dominate the biopharmaceutical sector due to their potency and efficacy against a range of disease targets. These proteinaceous therapeutics are, however, susceptible to unfolding, mis-folding, and aggregation by environmental perturbations. Aggregation thus poses an enormous challenge to biopharmaceutical development, production, formulation, and storage.

Casimir-Polder Size Consistency: A Constraint Violated by Some Dispersion Theories.

A key goal in quantum chemistry methods, whether ab initio or otherwise, is to achieve size consistency. In this work we formulate the related idea of "Casimir-Polder size consistency" that manifests in long-range dispersion energetics. We show that local approximations in time-dependent density functional theory dispersion energy calculations violate the consistency condition because of incorrect treatment of highly nonlocal "xc kernel" physics, by up to 10% in our tests on closed-shell atoms.

Inducing protein aggregation by extensional flow.

Relative to other extrinsic factors, the effects of hydrodynamic flow fields on protein stability and conformation remain poorly understood. Flow-induced protein remodeling and/or aggregation is observed both in Nature and during the large-scale industrial manufacture of proteins. Despite its ubiquity, the relationships between the type and magnitude of hydrodynamic flow, a protein's structure and stability, and the resultant aggregation propensity are unclear.

Sport-related concussion induces transient cardiovascular autonomic dysfunction.

Recent evidence suggests that concussions may disrupt autonomic cardiovascular control. This study investigated the initial effects of concussion on cardiovascular function using three autonomic reflex tests. Twenty-three recreational athletes (12 women, 11 men) were divided into concussed ( = 12) and control ( = 11) groups.

Spooky correlations and unusual van der Waals forces between gapless and near-gapless molecules.

We consider the zero-temperature van der Waals (vdW) interaction between two molecules, each of which has a zero or near-zero electronic gap between a ground state and the first excited state, using a toy model molecule (equilateral H) as an example. We show that the van der Waals energy between two ground state molecules falls off as D instead of the usual D dependence, when the molecules are separated by distance D. We show that this is caused by a perfect "spooky" correlation between the two fluctuating electric dipoles.

Distributed retrieval practice promotes superior recall of anatomy information.

Effortful retrieval produces greater long-term recall of information when compared to studying (i.e., reading), as do learning sessions that are distributed (i.

The benefit of self-testing and interleaving for synthesizing concepts across multiple physiology texts.

A testing-based learning strategy is one that relies on the act of recalling (i.e., testing) information after exposure, and interleaving is a strategy in which the learning materials are presented in a serial order (e.

Identifying Dosage Effect of Light-Emitting Diode Therapy on Muscular Fatigue in Quadriceps.

Hemmings, TJ, Kendall, KL, and Dobson, JL. Identifying dosage effect of light-emitting diode therapy on muscular fatigue in quadriceps. J Strength Cond Res 31(2): 395-402, 2017-The purpose of this study was to compare the effects of various dosages of light-emitting diode therapy (LEDT) on muscle fatigue while performing a single-leg extension to exhaustion.

Self-testing produces superior recall of both familiar and unfamiliar muscle information.

Dozens of studies have found learning strategies based on the "testing effect" promote greater recall than those that rely solely on reading; however, the advantages of testing are often only observed after a delay (e.g., 2-7 days later).

The effect of selected "desirable difficulties" on the ability to recall anatomy information.

"Desirable difficulties" is a theory from cognitive science used to promote learning in a variety of contexts. The basic premise is that creating a cognitively challenging environment at the learning acquisition phase, by actively engaging learners in the retrieval of to-be-learned materials, promotes long-term retention. In this study, the degree of desirable difficulties was varied to identify how cognitively challenging the learning acquisition phase must be to benefit university-level students' learning of anatomy concepts.

Self-testing promotes superior retention of anatomy and physiology information.

The testing effect shows that learning is enhanced by the act of recalling information after exposure. Although the testing effect is among the most robust findings in cognitive science, much of its empirical support is from laboratory studies and it has been applied as a strategy for enhancing learning in the classroom in a limited fashion. The purpose of this investigation was to replicate the testing effect in a university anatomy and physiology course and to extend the applicability of it to independent student study.

Benefits of exercise intervention in reducing neuropathic pain.

Peripheral neuropathy is a widespread and potentially incapacitating pathological condition that encompasses more than 100 different forms and manifestations of nerve damage. The diverse pathogenesis of peripheral neuropathy affects autonomic, motor and/or sensory neurons, and the symptoms that typify the condition are abnormal cutaneous sensation, muscle dysfunction and, most notably, chronic pain. Chronic neuropathic pain is difficult to treat and is often characterized by either exaggerated responses to painful stimuli (hyperalgesia) or pain resulting from stimuli that would not normally provoke pain (allodynia).

Binding and interlayer force in the near-contact region of two graphite slabs: experiment and theory.

Via a novel experiment, Liu et al. [Phys. Rev.