G-quadruplex stabilization provokes DNA breaks in human PKD1, revealing a second hit mechanism for ADPKD.

The "secondhit" pathway is responsible for biallelic inactivation of many tumor suppressors, where a pathogenic germline allele is joined by somatic mutation of the remaining functional allele. The mechanisms are unresolved, but the human PKD1 tumor suppressor is a good experimental model for identifying the molecular determinants. Inactivation of PKD1 results in autosomal dominant polycystic kidney disease, a very common disorder characterized by the accumulation of fluid-filled cysts and end-stage renal disease.

Age-related Variation in Sleep-dependent Obstruction in Surgically Naive Children.

Objective: Little is known about age-related variations in sites and grade of sleep-dependent airway obstruction in children with obstructive sleep apnea (OSA) or obstructive sleep-disordered breathing (oSDB). The objective was to compare sites and grade of obstruction on drug-induced sleep endoscopy (DISE) across different age groups of surgically naïve children with OSA or oSDB.

Methods: A retrospective chart review was performed for surgically naïve children aged 0-18 years with OSA/oSDB who underwent DISE from July 2021 to August 2023.

The influence of perioperative enoxaparin on bleeding after TORS oropharyngectomy.

Perioperative enoxaparin is often avoided in patients undergoing transoral robotic (TORS) oropharyngectomy. Our goal was to quantify the risk of postoperative hemorrhage (POH) in patients receiving enoxaparin after TORS oropharyngectomy. This was a retrospective database cohort study set up in 89 separate healthcare organizations.

Effect of perioperative ketorolac on postoperative bleeding after pediatric tonsillectomy.

Introduction: Ketorolac is a frequently used anesthetic pain agent which is traditionally avoided during tonsillectomy due to concern for postoperative hemorrhage. Our goal was to assess the degree of risk associated with the use of Ketorolac following pediatric tonsillectomy.

Methods: The TriNetX electronic health records research database was queried in January 2024 for patients undergoing tonsillectomy with or without adenoidectomy under the age of 18 years and without a diagnosed bleeding disorder.

Feelings of responsibility and temporal binding: A comparison of two measures of the sense of agency.

Temporal binding refers to a subjective shortening of the interval between an action and its perceptual consequences. Temporal binding has often been used by researchers to indirectly measure participants' sense of agency (SoA), or the subjective sense of causing something to happen. Other studies have proposed links between temporal binding and feelings of moral responsibility.

The Development of Head and Neck Cancer in Patients with the Isolated Complaint of Globus Pharyngeus.

Objectives: Globus pharyngeus (GP) is a perplexing problem that accounts for 4% of referrals to otolaryngologists. Workup can be extensive and may not be definitive in terms of etiology. The concern that lingers is that of a subtle cancer, which can prolong anxiety and increase testing cost.

Impact of recurrent acute rhinosinusitis on quality of life.

Quality of life (QoL) in patients with recurrent acute rhinosinusitis (RARS) is understudied. QoL for RARS patients is similar to chronic rhinosinusitis patients, although objective disease severity is lower. QoL of RARS patients is similarly affected during active and inactive infection.

Cognitive load decreases the sense of agency during continuous action.

The sense of agency that normally accompanies voluntary actions depends on a combination of sensory predictions and other inferences. For example, when people manipulate moving objects and rate their degree of control, control ratings are influenced by proximal correlations between motor commands and visual feedback as well as the overall success or failure of the action. The relative importance of sensory predictions vs.

Room-temperature valence transition in a strain-tuned perovskite oxide.

Cobalt oxides have long been understood to display intriguing phenomena known as spin-state crossovers, where the cobalt ion spin changes vs. temperature, pressure, etc. A very different situation was recently uncovered in praseodymium-containing cobalt oxides, where a first-order coupled spin-state/structural/metal-insulator transition occurs, driven by a remarkable praseodymium valence transition.

The Impact of Homemade Laparoscopic Box Trainers on Medical Student Surgical Skills: A Randomized Control Pilot Study.

While instructional videos are commonly used in surgical education, there is a paucity of data on home laparoscopic box trainers. This pilot study evaluated impacts of augmenting instructional videos with these devices. This was a randomized controlled pilot study evaluating laparoscopic surgical performance on the LapSim virtual surgical simulator before and after a 2 week curriculum of instructional videos alone (n = 8, 47.

Acute colonic pseudo-obstruction (Ogilvie syndrome) leading to respiratory compromise and death.

Here, we present an unusual case of acute colonic pseudo-obstruction (ACPO), also known as Ogilvie syndrome, which resulted in respiratory failure and sudden death. The patient was a 19-year-old man with a history of cerebral palsy (CP) and severe autism who experienced marked abdominal distension that progressed over several days in his skilled nursing facility. He developed shortness of breath and episodic diarrhea, before having an unwitnessed cardiac arrest and subsequently expiring after prehospital and emergency department care.

Empiric treatment for peritonsillar abscess: A single-center experience with medical therapy alone.

Purpose: Compare the use of medical therapy alone (MTA) with surgical therapy (ST) for the empiric treatment of peritonsillar abscess (PTA).

Materials And Methods: A consecutive cohort of patients treated for PTA at our institution from May 2013 to February 2019 was analyzed. Demographics, disease characteristics, management strategies, and treatment outcomes were compared between treatment groups.

Differentiating Pseudohyperkalemia From True Hyperkalemia in a Patient With Chronic Lymphocytic Leukemia and Diverticulitis.

Acute changes in electrolyte levels can result in severe physiologic complications. Rapid treatment of abnormally elevated potassium levels is essential due to the increased risk of potentially fatal cardiac arrhythmias. However, there are a number of circumstances that can lead to falsely elevated serum potassium levels, including fist clenching during phlebotomy and hemolysis of hematocytes during laboratory processing.

Individual Differences in Sensitivity to Visuomotor Discrepancies.

This study explored whether sensitivity to visuomotor discrepancies, specifically the ability to detect and respond to loss of control over a moving object, is associated with other psychological traits and abilities. College-aged adults performed a computerized tracking task which involved keeping a cursor centered on a moving target using keyboard controls. On some trials, the cursor became unresponsive to participants' keypresses.

Storm, rogue wave, or tsunami origin for megaclast deposits in western Ireland and North Island, New Zealand?

The origins of boulderite deposits are investigated with reference to the present-day foreshore of Annagh Head, NW Ireland, and the Lower Miocene Matheson Formation, New Zealand, to resolve disputes on their origin and to contrast and compare the deposits of tsunamis and storms. Field data indicate that the Matheson Formation, which contains boulders in excess of 140 tonnes, was produced by a 12- to 13-m-high tsunami with a period in the order of 1 h. The origin of the boulders at Annagh Head, which exceed 50 tonnes, is disputed.

A harbinger of plate tectonics: a commentary on Bullard, Everett and Smith (1965) 'The fit of the continents around the Atlantic'.

In the 1960s, geology was transformed by the paradigm of plate tectonics. The 1965 paper of Bullard, Everett and Smith was a linking transition between the theories of continental drift and plate tectonics. They showed, conclusively, that the continents around the Atlantic were once contiguous and that the Atlantic Ocean had grown at rates of a few centimetres per year since the Early Jurassic, about 160 Ma.

Do implicit and explicit measures of the sense of agency measure the same thing?

The sense of agency (SoA) refers to perceived causality of the self, i.e. the feeling of causing something to happen.

The phenomenology of controlling a moving object with another person.

The phenomenology of controlling what one perceives is influenced by a combination of sensory predictions and inferential processes. While it is known that external perturbations can reduce the sense of control over action effects, there have been few studies investigating the impact of intentional co-actors on the sense of control. In three experiments, we investigated how individuals' judgments of control (JoC) over a moving object were influenced by sharing control with a second person.

Predictable and self-initiated visual motion is judged to be slower than computer generated motion.

Self-initiated action effects are often perceived as less intense than identical but externally generated stimuli. It is thought that forward models within the sensorimotor system pre-activate cortical representations of predicted action effects, reducing perceptual sensitivity and attenuating neural responses. As self-agency and predictability are seldom manipulated simultaneously in behavioral experiments, it is unclear if self-other differences depend on predictable action effect contingencies, or if both self- and externally generated stimuli are modulated similarly by predictability.

When dyads act in parallel, a sense of agency for the auditory consequences depends on the order of the actions.

The sense of agency (SA) is the perception of willfully causing something to happen. Wegner and Wheatley (1999) proposed three prerequisites for SA: temporal contiguity between an action and its effect, congruence between predicted and observed effects, and exclusivity (absence of competing causal explanations). We investigated how temporal contiguity, congruence, and the order of two human agents' actions influenced SA on a task where participants rated feelings of self-agency for producing a tone.

Relationship between BOLD amplitude and pattern classification of orientation-selective activity in the human visual cortex.

Orientation-selective responses can be decoded from fMRI activity patterns in the human visual cortex, using multivariate pattern analysis (MVPA). To what extent do these feature-selective activity patterns depend on the strength and quality of the sensory input, and might the reliability of these activity patterns be predicted by the gross amplitude of the stimulus-driven BOLD response? Observers viewed oriented gratings that varied in luminance contrast (4, 20 or 100%) or spatial frequency (0.25, 1.

Is that what I wanted to do? Cued vocalizations influence the phenomenology of controlling a moving object.

The phenomenology of controlled action depends on comparisons between predicted and actually perceived sensory feedback called action-effects. We investigated if intervening task-irrelevant but semantically related information influences monitoring processes that give rise to a sense of control. Participants judged whether a moving box "obeyed" or "disobeyed" their own arrow keystrokes (Experiments 1 and 2) or visual cues representing the computer's choices (Experiment 3).

Taking credit for success: the phenomenology of control in a goal-directed task.

We studied how people determine when they are in control of objects. In a computer task, participants moved a virtual boat towards a goal using a joystick to investigate how subjective control is shaped by (1) correspondence between motor actions and the visual consequences of those actions, and (2) attainment of higher-level goals. In Experiment 1, random discrepancies from joystick input (noise) decreased judgments of control (JoCs), but discrepancies that brought the boat closer to the goal and increased success (the autopilot) increased JoCs.