Hypertension and the eye.

Purpose Of Review: This article reviews the findings of systemic hypertension in the eye and how these changes represent disease in the eye itself, as well as the predictive value of fundoscopic findings in relation to overall health. Systemic hypertension is associated with observable changes in the retinal microvasculature, including retinopathy, choroidopathy and optic neuropathy, as well as with an increased risk of ocular vascular abnormalities such as arterial and venous occlusive disease, retinal arteriolar macroaneurysm formation and embolic events. Hypertension also confers increased risk for development and progression of diabetic retinopathy, glaucoma and age-related macular degeneration.

Serous retinal detachment following glaucoma surgery.

The authors report the occurrence and clinical course of serous retinal detachment following glaucoma surgery in three patients. Serous detachment resolved in all patients spontaneously following treatment with oral and topical steroids.

Intravitreal toxicity of high-dose etanercept.

Purpose: The aim of this study was to evaluate the retinal toxicity of high-dose intravitreal etanercept, a U.S. Food and Drug Administration-approved anti-inflammatory drug, in the rabbit model.

Inhibition of corneal angiogenesis by ascorbic acid in the rat model.

Purpose: To evaluate the effect of topically administered ascorbic acid on experimentally induced corneal neovascularization in the rat model.

Materials And Methods: Corneal chemical cauterization of 72 eyes in Long-Evans male rats was performed using silver nitrate/potassium nitrate sticks. Nine groups of eight eyes were used to evaluate eight concentrations of ascorbic acid with one group of eight eyes serving as a control.

Intravitreal toxicity of garenoxacin.

Purpose: To assess the retinal toxicity of varying concentrations of intravitreally injected garenoxacin.

Methods: Twenty eyes of 20 New Zealand albino rabbits were used for this study. The animals were anesthetized with ketamine (35-50 mg/kg) and xylazine (3-5 mg/kg).