Severe neurotoxicity associated with exposure to the solvent 1-bromopropane (n-propyl bromide).

Background: 1-bromopropane was recently substituted for traditional ozone-depleting solvents in the industrial setting.

Case Series: We report a cohort of six cases of 1-bromopropane neurotoxicity occurring in foam cushion gluers exposed to 1-bromopropane vapors from spray adhesives. Patients 1-5 were exposed 30-40 hours per week over three years; patient 6 had been employed for the previous three months.

Anti-Hu antibodies in Merkel cell carcinoma.

Anti-Hu antibody is an antineuronal autoantibody found in a subset of patients with paraneoplastic neurological disease. The antibody was first associated with small cell carcinoma of the lung and is most often used as a marker for this neoplasm in patients presenting with suspected paraneoplastic syndromes. Here we report a patient with a multifaceted neurological disorder in the setting of Merkel cell carcinoma.