Publications by authors named "John D McGeagh"
Article Synopsis
- A study called Reach West was set up to help find people to join health-related research by reaching out to patients in outpatient clinics.
- They tested two ways to recruit participants: handing out information packs at clinics and mailing them directly to patients.
- The results showed that about 6% of people agreed to participate, mostly older adults, and they realized they need to find more ways to attract different kinds of participants in the future.
Large-scale conformational change is a common feature in the catalytic cycles of enzymes. Many enzymes function as homodimers with active sites that contain elements from both chains. Symmetric and anti-symmetric cooperative motions in homodimers can potentially lead to correlated active site opening and/or closure, likely to be important for ligand binding and release.
View Article and Find Full Text PDFThe role of protein dynamics in enzyme catalysis is one of the most active and controversial areas in enzymology today. Some researchers claim that protein dynamics are at the heart of enzyme catalytic efficiency, while others state that dynamics make no significant contribution to catalysis. What is the biochemist - or student - to make of the ferocious arguments in this area? Protein dynamics are complex and fascinating, as molecular dynamics simulations and experiments have shown.
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