Publications by authors named "John D Kakisis"

Endovascular stent grafting is becoming more common in treating complex thoracic aortic aneurysms and dissections. When it becomes necessary to cover the supra-aortic vessels, maintaining blood supply through the supra-aortic branches can be achieved by performing in situ needle fenestration. We present a case of a 65-year-old man with a type B aortic dissection that extended from the origin of the left subclavian artery.

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Article Synopsis
  • - Post Implantation Syndrome (PIS) affects some patients after endovascular aortic repair (EVAR), with a study of 76 patients revealing that 22% developed PIS, while the rest did not, indicating a potential link to systemic inflammatory response syndrome (SIRS).
  • - The study compared various factors, including platelet count and thrombus volume, between PIS and non-PIS groups; results showed higher baseline platelet counts and larger drops in platelet counts among PIS patients but no significant differences in aneurysm volumes.
  • - The findings suggest that platelets are key indicators for developing PIS post-EVAR, highlighting the need for further research to clarify the relationship between platelets and thrombus volumes in this context
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It has been documented that large-artery stiffness is independently associated with increased cardiovascular risk and may potentially lead to heart and kidney failure and cerebrovascular disease. A systematic review of studies investigating changes in arterial stiffness in patients undergoing endovascular repair of aortic disease was conducted. In addition, a review of the available literature was performed, analyzing findings from studies using the cardio-ankle vascular index (CAVI) as a marker of arterial stiffness.

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Background:  Coarctation of the aorta (CoA) is a congenital cardiovascular malformation involving narrowing of the thoracic aorta just distal to the left subclavian artery. The aim of our study was to evaluate the hemodynamic effects of endovascular treatment for CoA by using invasive aortic catheterization.

Methods:  All patients with CoA who underwent treatment by aortic stent implantation between September 1, 2003, and February 1, 2019, at the "Onassis Cardiac Surgery Center," in Athens, Greece, were evaluated.

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Arterial stiffness and its valid index, the cardio-ankle vascular index (CAVI), have emerged as predictors of adverse cardiovascular outcomes. We investigated the relationship of the CAVI with significant carotid stenosis (> 50%) and the related cerebrovascular symptoms or carotid plaque echogenicity, assessed by ultrasound gray-scale median (GSM) score, at baseline and after carotid artery stenting (CAS). We prospectively enrolled 113 patients with carotid stenosis (70-99% for asymptomatic and > 50% for symptomatic participants) eligible for CAS.

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Preservation of the hypogastric circulation is of major clinical importance in cases of endovascular aneurysm repair (EVAR) for ruptured abdominal aortic aneurysm (rAAA). Pelvic ischemia can be detrimental and significantly increase post-operative morbidity and mortality. However, the application of a side branch device or a bell-bottom graft is not possible in ruptured aortoiliac aneurysms (due to off-the-shelf unavailability and/or prolonged operative time) and in most cases pelvic circulation may have to be sacrificed.

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Article Synopsis
  • Both abdominal wall hernias (AWHs) and abdominal aortic aneurysms (AAAs) often occur in older men and have been linked in previous research.
  • A systematic review and meta-analysis of 17 studies with over 738,000 participants found that patients with AWHs have a higher incidence of AAAs, and those with AAAs are more likely to have AWHs.
  • The results suggest that screening for AAAs could include checking for AWHs, in addition to considering factors like age, gender, family history, and smoking habits.
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  • Aortic neck wall rupture is a rare but serious complication that can occur during endovascular repair of abdominal aortic aneurysms (EVAR), often linked to repeated balloon inflation attempts for treating Type 1a endoleaks.
  • The study reviewed 824 EVAR procedures from 2009 to 2019, identifying three instances of aortic neck wall rupture, all related to Type 1a endoleaks, with conversion to open repair being necessary in each case, yet all patients survived.
  • The findings suggest limiting balloon attempts to two for Type 1a endoleaks and emphasize the urgency of controlling hemorrhage and performing emergency surgical conversions to mitigate risks associated with such a complication.
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Article Synopsis
  • Transcervical carotid artery stenting (CAS) is presented as a safe alternative to transfemoral CAS, showing low stroke and complication rates according to an updated systematic review that included nearly 1600 additional patients.
  • A thorough search revealed 18 studies conducted on 2110 procedures, documenting high technical success (98.25%) and low mortality (0.48%), with minimal neurological complications and hematoma occurrences.
  • The meta-analysis confirmed a pooled technical success rate of 98.69%, a mortality rate of only 0.04%, and a low incidence of major neurological complications, highlighting the effectiveness of transcervical CAS with flow reversal.
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Pulse wave velocity (PWV) is a valid, clinically feasible marker of arterial stiffening, and a strong predictor of outcomes. The present study aimed to compare aortic elastic properties in patients with abdominal aortic aneurysms (AAA), with or without coronary artery disease (CAD), as well as healthy individuals. A total of 130 patients with AAA, eligible for interventional repair, and 30 healthy individuals, comprising the control group (HC), were enrolled.

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Objective: Common iliac artery aneurysms are present in more than a third of patients with abdominal aortic aneurysm and may pose a challenge during open and endovascular repair. Although embolization of the internal iliac artery is an established method, it may be complicated with buttock claudication, erectile dysfunction, colon ischemia, and pelvic necrosis. Iliac branch devices (IBDs), which permit preservation of the hypogastric artery, have been used to prevent these complications.

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Backround & Purpose: Perioperative neck hematoma (PNH) requiring re-intervention is an important complication after carotid endarterectomy (CEA). There are limited data regarding the potential risk factors associated with PNH. The aim of this prospective, multicenter study was to document the rate of PNH in symptomatic carotid artery stenosis (sCAS) patients treated with CEA within the first 14 days of cerebrovascular symptom onset and to identify possible predictors of this complication.

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Background: Type Ia endoleak due to inadequate seal at the proximal end of the endograft is not infrequent during the initial operation. However, repeated attempts at balloon inflation or over-dilatation of the balloon can produce high axial pressures and can lead to aortic neck rupture with hemodynamic instability.

Methods: The purpose of the paper is to present a useful technique for simultaneously treating a type Ia endoleak and aortic neck rupture during endovascular abdominal aortic aneurysm repair.

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Extracranial internal carotid artery (ICA) aneurysms are rare and most of them are considered of atherosclerotic etiology. Marfan syndrome (MS) is a systemic connective tissue disorder caused by mutation in the extracellular matrix protein fibrillin 1. Clinical manifestations of the MS include aortic aneurysms, dislocation of the ocular lens, and long bone overgrowth.

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Angiosarcomas developing in nonfunctioning arteriovenous fistulas in renal transplant recipients are quite rare clinical entities with very poor prognosis. Herein we present a 60-year-old male who developed an angiosarcoma in a thrombosed radiocephalic fistula 6 years after renal transplantation. The patient presented with pain and swelling at the site of a previously asymptomatic fistula.

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