Publications by authors named "John D Hofbauer"
Purpose: To describe a corneal endothelial layer and Descemet membrane transplantation into the anterior chamber for the treatment of bullous keratopathy in 1980.
Methods: A retrospective report of an intervention case study is presented. A patient with aphakic bullous keratopathy in one eye was interested in undergoing a previously untested corneal transplantation procedure.
Purpose: To report the identification and characterization of stromal amyloid deposits in patients with keratoconus.
Methods: The excised corneal buttons from 2 patients diagnosed clinically with keratoconus underwent histochemical analysis with Masson trichrome, Congo red, Alcian blue, and periodic acid-Schiff stains, and immunohistochemical analysis for the transforming growth factor beta-induced gene (TGFBI) protein product (TGFBIp), prealbumin, lysozyme, and kappa and lambda light chain expression. After the collection of DNA from both patients, exons 4, 11, 12, 13 and 14 of TGFBI were amplified and sequenced to search for mutations previously associated with dystrophic corneal stromal amyloid deposition.