Pharmaceutical quality of "party pills" raises additional safety concerns in the use of illicit recreational drugs.

Aim: To determine the content and release kinetics of 1-benzylpiperazine (BZP) and 1-(3-trifluoromethyl-phenyl)piperazine (TFMPP) from "party pill" formulations. From these data, the possible impact of pharmaceutical quality upon the safety of such illicit formulations may be inferred.

Methods: The amount of BZP and TFMPP in party pill formulations was determined using a validated HPLC method.