Publications by authors named "John Cordero"
Article Synopsis
- Girdlestone resection arthroplasty (GRA) is an option for patients unable to have prosthesis reimplantation due to infection, and this study investigates factors influencing reimplantation using a large database from 2012-2015.
- Out of 2,772 GRA cases, 73.1% were successfully reimplanted, with a median reimplantation time of 3 months, and factors like age, race, obesity, and comorbidities negatively impacted the likelihood of reimplantation.
- The study highlights that male patients had higher odds for reimplantation, suggesting a need for further research into the reasons behind the variability in patient outcomes after GRA.
Article Synopsis
- Randomized controlled trials (RCTs) are considered the most reliable evidence in orthopedic surgery, but their statistical findings can sometimes lack stability, which this study aimed to investigate using fragility metrics.
- The researchers analyzed 108 RCTs on tranexamic acid (TXA) in orthopedic surgery, finding that many outcomes are "fragile" and small changes could affect their statistical significance.
- The study suggests using fragility index (FI), reverse fragility index (rFI), and fragility quotient (FQ) to better interpret the results of these trials in the future.
Article Synopsis
- The study evaluated the statistical stability of outcomes from randomized controlled trials (RCTs) focusing on the management of femoral neck fractures, using metrics like fragility index (FI), reverse fragility index (rFI), and fragility quotient (FQ).
- After screening 985 articles, 71 studies were analyzed, revealing a median FI of 4, indicating that a small number of event reversals could change the statistical significance of findings.
- The results suggest that many outcomes in these RCTs are fragile, prompting the authors to recommend standardized reporting of P-values to improve the reliability of the data.
Article Synopsis
- This study analyzes the fragility of outcomes in orthopaedic research, particularly regarding periprosthetic joint infection (PJI) in total joint arthroplasty randomized controlled trials (RCTs) published from 2010 to 2022.
- It utilizes the fragility index (FI) and fragility quotient (FQ) to assess how many event reversals are needed to change the significance of the outcomes and reveals that many outcomes are statistically weak.
- The findings highlight the importance of conducting fragility analyses to better interpret outcomes in orthopaedic studies, indicating that many reported results may not be statistically robust.
Article Synopsis
- The study evaluates the statistical reliability of randomized controlled trials (RCTs) comparing hamstring tendon and bone-patellar tendon-bone autografts for ACL reconstruction published since 2010.
- Researchers identified 19 RCTs and found that many outcomes showed statistical fragility, meaning that only a small number of outcome changes could flip the findings from significant to nonsignificant or vice versa.
- Over half of the outcomes had patient losses that could influence results, indicating that these studies may not provide robust evidence for the best graft choice in ACL surgery.
Development and validation of rapid and easy-to-perform diagnostics continue to be a high priority during the current COVID-19 pandemic. Although vaccines are now widely available, early detection and consistent transmission control provide ideal means to mitigate the spread of SARS-CoV-2. Nucleic acid-based real-time PCR tests are widely acknowledged as the gold standard for reliable diagnosis of COVID-19 infection.
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- The study focuses on evaluating the statistical fragility of randomized controlled trials (RCTs) related to tourniquet use in total knee arthroplasty (TKA), particularly how P-values are used to inform clinical decisions.
- Investigators analyzed data from 23 studies, calculating the fragility index (FI) and fragility quotient (FQ) to determine how many outcome reversals would affect the significance of their findings, revealing an overall median FI of 4.
- The results suggest that minor changes in outcomes can significantly alter study conclusions, highlighting the importance of fragility analyses for enhancing the reliability of research interpretations in clinical settings.
Development of In Vitro Bioengineered Vascular Grafts for Microsurgery and Vascular Surgery Applications.
Plast Reconstr Surg Glob Open
May 2019
Introduction: The use of vascular grafts is continuing to rise due to the increasing prevalence of coronary artery bypass grafting and microvascular flap-based tissue reconstructions. The current options of using native vessels (saphenous vein) or the synthetic grafts (Dacron) have been unable to manage current needs. In this study, we employed an original tissue engineering approach to develop a multi-layered vascular graft that has the potential to address some of the limitations of the existing grafts.
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