Publications by authors named "John Catchpole"
Microbiology (Reading)
June 2016
Article Synopsis
- AIEC (Adherent-invasive Escherichia coli) is linked to Crohn's disease by triggering inflammation through high cytokine production in infected macrophages.
- AIEC can replicate within macrophages, and this study found that their replication relies on bacterial glycolysis, suggesting a metabolic dependency.
- The macrophage response to AIEC infection is similar to that of a non-replicating glycolysis mutant and a harmless strain of E. coli, indicating that AIEC does not disrupt the typical macrophage response during infection.
