The fundamental theorem of natural selection with mutations.

The mutation-selection process is the most fundamental mechanism of evolution. In 1935, R. A.

A new look at an old virus: patterns of mutation accumulation in the human H1N1 influenza virus since 1918.

Background: The H1N1 influenza A virus has been circulating in the human population for over 95 years, first manifesting itself in the pandemic of 1917-1918. Initial mortality was extremely high, but dropped exponentially over time. Influenza viruses have high mutation rates, and H1N1 has undergone significant genetic changes since 1918.

The effects of low-impact mutations in digital organisms.

Background: Avida is a computer program that performs evolution experiments with digital organisms. Previous work has used the program to study the evolutionary origin of complex features, namely logic operations, but has consistently used extremely large mutational fitness effects. The present study uses Avida to better understand the role of low-impact mutations in evolution.

Skittle: a 2-dimensional genome visualization tool.

Background: It is increasingly evident that there are multiple and overlapping patterns within the genome, and that these patterns contain different types of information--regarding both genome function and genome history. In order to discover additional genomic patterns which may have biological significance, novel strategies are required. To partially address this need, we introduce a new data visualization tool entitled Skittle.