A new Cylindromatosis (CYLD) gene mutation in a case of Brooke-Spiegler syndrome masquerading as basal cell carcinoma of the eyelids.

A 70-year-old woman sought treatment for confluent flesh-colored papules on all 4 eyelids. Sixteen family members were reported to have similar lesions involving the face and scalp. Initial histopathologic examination of the lesions was interpreted as basal cell carcinoma, but on further review, the lesions were deemed to be consistent with trichoepitheliomas as seen in Brooke-Spiegler syndrome.

Multiple significant bortezomib-related toxicities in one patient: case report and literature review.

Bortezomib has shown significant efficacy in the treatment of patients with relapsed multiple myeloma (MM) and is generally well tolerated. We report a 65-year-old male patient undergoing bortezomib therapy for MM who, with the addition of liposomal doxorubicin, presented with severe paralytic ileus, peripheral neuropathy, pruritic rash, and testicular pain. Each of these toxicities was temporally related to the bortezomib-based therapy and the administration of concomitant liposomal doxorubicin.

Cystic orbital metastasis from endometrial carcinoma.

Purpose: To describe a rare orbital metastasis with atypical presentation.

Design And Methods: Retrospective case report.

Results: The patient presented with a rapid onset of a cystic orbital lesion after a presumptive diagnosis of endometrial carcinoma that had been completely excised eight months ago.