Penicillin minor determinants: History and relevance for current diagnosis.

Objective: To review the history of the penicillin minor determinants and evaluate their relevance for current diagnosis.

Data Sources: Skin testing to detect immunoglobulin E (IgE) sensitivity to penicillins in patients with a history of penicillin allergy has been the subject of more than 55 years of published research involving tens of thousands of patients.

Study Selections: Selection of data was based on its relevance to the objective of this article.