Publications by authors named "John C Ambrose"
In mammals, faithful inheritance of genomic methylation patterns ensures proper gene regulation and cell behaviour, impacting normal development and fertility. Following establishment, genomic methylation patterns are transmitted through S-phase by the maintenance methyltransferase Dnmt1. Using a protein interaction screen, we identify Microprocessor component DROSHA as a novel DNMT1-interactor.
View Article and Find Full Text PDFEpigenome-wide association studies (EWAS) provide an alternative approach for studying human disease through consideration of non-genetic variants such as altered DNA methylation. To advance the complex interpretation of EWAS, we developed eFORGE (http://eforge.cs.
View Article and Find Full Text PDFBackground: An increase in non-B HIV-1 infections among men who have sex with men (MSM) in the United Kingdom (UK) has created opportunities for novel recombinants to arise and become established. We used molecular mapping to characterize the importance of such recombinants to the UK HIV epidemic, in order to gain insights into transmission dynamics that can inform control strategies.
Methods And Results: A total of 55,556 pol (reverse transcriptase and protease) sequences in the UK HIV Drug Resistance Database were analyzed using Subtype Classification Using Evolutionary Algorithms (SCUEAL).
Article Synopsis
- Independent mutations on mouse chromosome 4 have been linked to dominant head-bobbing and circling behaviors caused by truncations in the inner ear's lateral semicircular canal.
- Researchers identified mutations in the Chd7 gene in several of these mutants, which are connected to CHARGE syndrome in humans, known for causing inner ear malformations and other varying defects.
- The widespread expression of Chd7 during development correlates with a range of defects in heterozygous mutant mice, mirroring CHARGE syndrome features and suggesting that both mouse and human mutations may stem from Chd7's large size and the viability of many carriers with observable traits.