as a Source of Quorum Sensing Inhibitors to Combat Antibiotic Resistance of Human and Aquaculture Pathogens.

Biofilms play a decisive role in the infectious process and the development of antibiotic resistance. The establishment of bacterial biofilms is regulated by a signal-mediated cell-cell communication process called "quorum sensing" (QS). The identification of quorum sensing inhibitors (QSI) to mitigate the QS process may facilitate the development of novel treatment strategies for biofilm-based infections.

AHL-Lactonase Producing sp. From Palk Bay Sediment Mitigates Quorum Sensing-Mediated Virulence Production in Gram Negative Bacterial Pathogens.

Quorum sensing (QS) is a signaling mechanism governed by bacteria used to converse at inter- and intra-species levels through small self-produced chemicals called N-acylhomoserine lactones (AHLs). Through QS, bacteria regulate and organize the virulence factors' production, including biofilm formation. AHLs can be degraded by an action called quorum quenching (QQ) and hence QQ strategy can effectively be employed to combat biofilm-associated bacterial pathogenesis.

The control of microbially induced corrosion by methyl eugenol - A dietary phytochemical with quorum sensing inhibitory potential.

The development of biofilms by microorganisms is conventionally attributed to microbially induced corrosion on stainless steel surfaces and leads to severe consequences in industrial and environmental settings. Since bacterial biofilm formation is regulated by the signal mediated quorum sensing (QS) system, targeting biofilms through QS inhibitors will possibly control biologically induced corrosion on the metal surface. In this study, biofilm formation on 316L stainless steel (SS 316L) immersed in a natural pond water system was effectively inhibited in the presence of the QS inhibitor methyl eugenol, as evidenced through epifluorescence microscopy, confocal laser scanning microscopy (CLSM) and scanning electron microscopy (SEM) analyses.