Point-of-Care Ultrasound Curriculum for Internal Medicine Residents During the COVID-19 Era: A Pilot Study.

Introduction: The use of point-of-care ultrasound (POCUS) by internal medicine physicians and residents is increasing. We present the results of a pilot study to implement a POCUS curriculum that was interrupted by the Coronavirus Disease 2019 (COVID-19) pandemic at an internal medicine residency program at a community hospital. The purpose of this study is to inquire about the attitude and interest of our medical residents in POCUS.

Scenarios of intermittent E. coli contamination from sewer overflows to shellfish growing waters: The Dart Estuary case study.

Sewage overflows (SOs) and Combined Sewer Overflows (CSOs) significantly contribute to the bacterial contamination of coastal waters, which is of especial concern for aquaculture, a growing industry worldwide. Hydrodynamic and water quality models were used to investigate impacts of CSO discharge frequency and duration, river discharge and tides on Escherichia coli levels at shellfish farming sites in the Dart Estuary (UK), being the employed methodology generally applicable. High E.

Increased dispersion of oil from a deep water seabed release by energetic mesoscale eddies.

Hydrodynamics play a critical role in determining the trajectory of an oil spill. Currents, stratification and mesoscale processes all contribute to how a spill behaves. Using an industry‑leading oil spill model, we compare forecasts of oil dispersion when forced with two different hydrodynamic models of the North-West European Shelf (7 km and 1.

Modelling pollution dispersal around Solomon Islands and Vanuatu.

To assess potential dispersion of pollutants around Honiara, Solomon Islands, and Port Vila, Vanuatu, 3D ocean circulation models were developed using Telemac-3D. A series of scenarios then explore the vulnerability of the system and test potential control measures. Results show that high coastal concentrations are most likely during the wet season, with increased volumes of discharge as well as favourable wind speed and direction.

Interleukin-12 and -23 blockade mitigates elastase-induced abdominal aortic aneurysm.

Macrophages play an important role in the inflammatory process that contributes to the development of abdominal aortic aneurysm (AAA). Studies of human and mouse AAA tissue reveal expanded populations of macrophages producing an abundance of pro-inflammatory cytokines, including TNF-α, IL-12p40 and high level of metalloprotease 9 (MMP-9) at the late stages of disease. Herein, we show that blockade of IL-12p40 in the early phase of aneurysm development suppresses macrophage expansion, inflammatory cytokine and MMP-9 production and mitigates AAA development.

Anti-JNK2 peptide-siRNA nanostructures improve plaque endothelium and reduce thrombotic risk in atherosclerotic mice.

Background: A direct and independent role of inflammation in atherothrombosis was recently highlighted by the Canakinumab Antiinflammatory Thrombosis Outcome Study (CANTOS) trial, showing the benefit of inhibiting signaling molecules, eg, interleukins. Accordingly, we sought to devise a flexible platform for preventing the inflammatory drivers at their source to preserve plaque endothelium and mitigate procoagulant risk.

Methods: p5RHH-siRNA nanoparticles were formulated through self-assembly processes.

The effects of functional limitations on soldier common tasks.

This paper describes the findings associated with the ability of an individual to perform the United States Army's Common Soldier Tasks of: "Maintaining an M16-Series Rifle" , "Protect Yourself from Chemical, Biological, Radiological, and Nuclear (CBRN) Injury or Contamination with Mission-Oriented Protective Posture (MOPP) Gear", and "Protect Yourself from Chemical and Biological (CB) Contamination Using Your Assigned Protective Mask." The analysis was conducted using data compiled from videos of a Soldier performing the given tasks at Walter Reed Army Medical Center. The findings reflect the opinions of researchers in identifying potential elements, which impose abnormal, irregular, and/or extraneous effort when performing the tasks as outlined in STP-21-1-SMCT - Soldier's Manual of Common Tasks: Skill Level I.