Publications by authors named "John B Copley"

Article Synopsis
  • Concerns about the safety of lanthanum carbonate, a phosphate binder, continue despite a decade of monitoring, but studies show no evidence of aluminum-like toxicity or accumulation.
  • Lanthanum is minimally absorbed and eliminated mainly through the liver, unlike aluminum, which the kidneys process; bone biopsies and liver function tests have shown no harmful effects in patients.
  • Analysis of a large observational study indicates that patients on lanthanum carbonate have similar or improved survival rates compared to those on other phosphate binders, with low rates of bone fractures and a lack of significant safety issues over extensive patient exposure.
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Left uncontrolled, persistent post-kidney transplant hyperparathyroidism (HPT) may lead to or exacerbate pre-existing bone and cardiovascular disease. Parathyroidectomy has long been the primary treatment option for long-term uncontrolled HPT in post-kidney transplant patients. However, patients with contraindications for surgery and parathyroidectomy-associated complications, including graft loss, highlight the need for other approaches.

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Renal artery stenosis (RAS) is a significant cause of secondary hypertension, the progression of which can lead to renal insufficiency, uncontrolled hypertension, and even end-stage renal disease. The 2 most common forms of RAS are atherosclerotic renovascular disease and fibromuscular dysplasia (FMD). Atherosclerosis accounts for 90% of all cases of RAS and generally affects an elderly population.

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There is experimental evidence but very few human studies that suggest a role for obesity in the formation and progression of some glomerular lesions. We report the case of a morbidly obese male with hematuria and proteinuria that was subsequently diagnosed with renal failure which required dialysis. Histological findings of the renal biopsy performed during a laparoscopic gastric bypass are presented.

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