Publications by authors named "John A L Short"
Article Synopsis
- Copyback defective virus genomes (DVGs) are mistakenly produced during the replication of parainfluenza virus 5 and act as strong inducers of the innate immune response, particularly the interferon (IFN) response.
- High levels of nondefective (ND) virus can inhibit DVGs from activating the IFN response, while DVGs can interfere with ND virus replication.
- Research reveals that DVGs invoke an uncharacterized innate response that curtails their own replication and suggests there are inherent regional, size, and structural preferences in their amplification, highlighting their potential therapeutic use in antiviral strategies.
