Publications by authors named "John A Humphrey"
We present the first case report of successful cardiac surgery in a child with idiopathic infantile arterial calcification (IIAC), a disease that is generally lethal within the first 6 months of life. This 27-month-old Hispanic American boy with IIAC successfully underwent cardiothoracic surgery for severe pulmonary valve (PV) stenosis after unsuccessful balloon valvotomy in the cardiac catheterization laboratory.
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- Volatile anesthetics like halothane and enflurane selectively affect higher conscious functions, prompting research into their genetic interactions.
- Mutations in two specific genes from the roundworm (Caenorhabditis) and fruit fly (Drosophila) show varying effects on responses to these anesthetics, indicating that not all volatiles are influenced equally by genetic variants.
- Studies reveal that the orthologs of these genes are functionally related and suggest that they play a crucial role in the mechanisms of anesthetic action, making these genes important for understanding how anesthetics work.
The discovery of the phenomenon of anesthesia over 150 years ago was a watershed event that revolutionized the practice of medicine. Despite their annual use in millions of patients, the mechanism by which volatile anesthetics produce reversible loss of consciousness remains a mystery. The inherent problems in studying loss of consciousness in humans are legion.
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