Clinical and hematological effects of serial phlebotomy performed on laboratory beagles.

We conducted a study designed to mimic a typical pharmacokinetic study to gain a better understanding of a dog's response to multiple, frequent blood sampling at 15% total blood volume. Ten dogs were randomly assigned to either a control group having sham venipuncture performed or to a blood collection group having 1.5% of their body weight (approximately 15% total blood volume) removed weekly for 4 weeks.