Impact of volume expansion on the efficacy and pharmacokinetics of liposome bupivacaine.

Liposome bupivacaine is a prolonged-release liposomal formulation of bupivacaine indicated for single-dose infiltration into the surgical site to produce postsurgical analgesia of longer duration than traditional local anesthetics. This review summarizes the available data on how volume expansion may impact the analgesic efficacy of liposome bupivacaine. The Phase II and III clinical studies that involved surgical site administration of liposome bupivacaine at various concentrations in different surgical settings revealed no apparent concentration-efficacy relationship.

Patterns of microbiology in intra-abdominal packing for trauma.

Introduction: This study tracks the microbiology of packs and infections in damage-control trauma patients to determine whether the packs cause infections.

Methods: The peritoneum and abdominal packs were cultured in patients who survived to re-operation. The study recorded all positive cultures, pack count, packing duration, number of operations, and infections.