Interleukin 1 receptor antagonist () gene variants predict radiographic severity of knee osteoarthritis and risk of incident disease.

Objective: In these studies, we examined the association of single nucleotide polymorphisms (SNPs) of the gene with radiographic severity of symptomatic knee osteoarthritis (SKOA) and the risk of incident OA. We also explored these genetic polymorphisms in patients with new onset rheumatoid arthritis (RA).

Methods: Over 1000 subjects who met American College of Rheumatology criteria for tibiofemoral OA were selected from three independent, National Institute of Health (NIH)-funded cohorts.