Identification of potential bioactive compounds of leaf extract against colon adenocarcinoma cells.

Plant bioactive compounds such as flavonoids and triterpenes can affect lipid metabolism. Here, we report the cytotoxic and lipid-lowering activities of the ethanolic extract of leaves on human colon adenocarcinoma SW480 cells, also the molecular interactions of bioactive compounds present in extract on ACC and HMGCR enzymes. The extract reduced cell viability and decreased intracellular triglyceride content by up to 35% and 28% at 24 and 48 h, respectively; whereas the effect was evident on cholesterol only at 24 h.

Inhibition of Cell Proliferation and Induction of Cell Cycle Arrest in Colon Cancer Cells by Lyophilized Mango ( L.) Pulp Extract.

The present study evaluated the antiproliferative capacity and possible cell death mechanisms of lyophilized mango pulp extract (LMPE), applied to human colon cancer cells (SW480) and their metastasis-derived counterparts (SW620). The total phenolic content of LMPE was estimated by the Folin-Ciocalteu method. Three assays were employed to determine its antioxidant capacity: ferric-reducing antioxidant power, oxygen radical absorbance capacity, and 2,2-diphenyl-1-picrylhydrazyl.

Impact of in vitro gastrointestinal digestion on the bioaccessibility and antioxidant capacity of bioactive compounds from Passion fruit (Passiflora edulis) leaves and juice extracts.

The fruits consumption is highly associated with a lessening in the risk of the chronic noncommunicable diseases. Despite their content of bioactive compounds, physiological conditions might affect their bioaccessibility and biological potential. Hence, the purpose of this research was to evaluate the bioaccessibility and in vitro antioxidant capacity of bioactive compounds (polyphenols, ascorbic acid, and mono/oligosaccharides) from passion fruit (Passiflora edulis) juice and leaves extracts (PJE and PLE, respectively) during an in vitro gastrointestinal digestion.