Cardiac MRI in infarct-like myocarditis: transmural extension of late gadolinium enhancement is associated with worse outcomes.

Objectives: To assess the prognostic value of cardiac MRI (CMR) parameters for the occurrence of major adverse cardiac events (MACE) in patients with infarct-like myocarditis.

Methods: In this retrospective single-center study, patients with CMR-confirmed acute myocarditis with infarct-like presentation were identified (2007-2020). Functional and structural parameters were analyzed including late gadolinium enhancement (LGE).

Modeling the velocity of evolving lineages and predicting dispersal patterns.

Accurate estimation of the dispersal velocity or speed of evolving organisms is no mean feat. In fact, existing probabilistic models in phylogeography or spatial population genetics generally do not provide an adequate framework to define velocity in a relevant manner. For instance, the very concept of instantaneous speed simply does not exist under one of the most popular approaches that models the evolution of spatial coordinates as Brownian trajectories running along a phylogeny (Lemey et al.

On the connections between the spatial Lambda-Fleming-Viot model and other processes for analysing geo-referenced genetic data.

The introduction of the spatial Lambda-Fleming-Viot model (ΛV) in population genetics was mainly driven by the pioneering work of Alison Etheridge, in collaboration with Nick Barton and Amandine Véber about ten years ago (Barton et al., 2010; Barton et al., 2013).

Rate of coalescence of lineage pairs in the Spatial Λ-Fleming-Viot process.

We revisit the Spatial Λ-Fleming-Viot process introduced in Barton and Kelleher (2010). Particularly, we are interested in the time T to the most recent common ancestor for two lineages. We distinguish between the cases where the process acts on the two-dimensional plane and on a finite rectangle.

The Evolving Moran Genealogy.

We study the evolution of the population genealogy in the classic neutral Moran Model of finite size n∈N and in discrete time. The stochastic transformations that shape a Moran population can be realized directly on its genealogy and give rise to a process on a state space consisting of n-sized binary increasing trees. We derive a number of properties of this process, and show that they are in agreement with existing results on the infinite-population limit of the Moran Model.

A common genomic code for chromatin architecture and recombination landscape.

Recent findings established a link between DNA sequence composition and interphase chromatin architecture and explained the evolutionary conservation of TADs (Topologically Associated Domains) and LADs (Lamina Associated Domains) in mammals. This prompted us to analyse conformation capture and recombination rate data to study the relationship between chromatin architecture and recombination landscape of human and mouse genomes. The results reveal that: (1) low recombination domains and blocks of elevated linkage disequilibrium tend to coincide with TADs and isochores, indicating co-evolving regulatory elements and genes in insulated neighbourhoods; (2) double strand break (DSB) and recombination frequencies increase in the short loops of GC-rich TADs, whereas recombination cold spots are typical of LADs and (3) the binding and loading of proteins, which are critical for DSB and meiotic recombination (SPO11, DMC1, H3K4me3 and PRMD9) are higher in GC-rich TADs.