Diagnostic and Prognostic Implications of Caspase-1 and PD-L1 Co-Expression Patterns in Myelodysplastic Syndromes.

Background: The inflammasome plays an essential role in lower risk MDS and immune subversion, with the up-regulation of immune checkpoint molecules in the progression to higher-risk disease. In this study, we explored the utility of immune-related biomarkers for the diagnosis and prognosis of MDS.

Methods: We performed an exploratory, case-control study with 20 randomly selected MDS patients and nine controls with non-inflammatory ( = 3) and inflammatory conditions ( = 6).