Pathophysiological central nervous system changes in a porcine model of acetaminophen-induced acute liver failure.

Background: Critical care management of patients suffering from acute liver failure (ALF) continues to be challenging. Animal models studying the pathophysiological central nervous system alterations during the course of ALF provide an opportunity to improve diagnostic and therapeutic strategies. The aim of this study was to analyse the course of cerebral oxygenation in addition to conventional neuromonitoring during the course of acetaminophen-induced ALF.

The enterohepatic circulation of amanitin: kinetics and therapeutical implications.

Background: Amatoxin poisoning induces a delayed onset of acute liver failure which might be explained by the prolonged persistence of the toxin in the enterohepatic circulation. Aim of the study was to demonstrate amanitin kinetics in the enterohepatic circulation.

Methods: Four pigs underwent α-amanitin intoxication receiving 0.