2-[18F]F-p-aminobenzoic acid specifically detects infective endocarditis in positron emission tomography.

Background: To the present day infective endocarditis (IE) represents a life-threatening disease with high mortality rate especially when caused by Staphylococcus aureus (S. aureus), the most common causative pathogen in this disease. Diagnosis of IE is based on clinical manifestations, pathogen detection by blood cultures and echocardiographic or other imaging findings.

DoE Optimization Empowers the Automated Preparation of Enantiomerically Pure [F]Talazoparib and its Evaluation as a PARP Radiotracer.

Given the clinical potential of poly(ADP-ribose) polymerases (PARP) imaging for the detection and stratification of various cancers, the development of novel PARP imaging probes with improved pharmacological profiles over established PARP imaging agents is warranted. Here, we present a novel F-labeled PARP radiotracer based on the clinically superior PARP inhibitor talazoparib. An automated radiosynthesis of [F]talazoparib (RCY: 13 ± 3.

Two experts and a newbie: [F]PARPi vs [F]FTT vs [F]FPyPARP-a comparison of PARP imaging agents.

Purpose: Imaging of PARP expression has emerged as valuable strategy for prediction of tumor malignancy. While [F]PARPi and [F]FTT are already in clinical translation, both suffer from mainly hepatobiliary clearance hampering their use for detection of abdominal lesions, e.g.