Publications by authors named "Johannes Hoefer"
Article Synopsis
- CD40L-CD40-TRAF signaling is implicated in the progression of atherosclerosis and the pathogenesis of coronary heart disease (CHD), especially in individuals with comorbid conditions like hyperlipidemia, diabetes, and hypertension.
- In mouse models with diabetes and hypertension, treatment with a TRAF6 inhibitor showed promising results by normalizing oxidative stress and inflammation markers, suggesting that this signaling pathway could serve as a therapeutic target.
- Analysis of plasma and vascular materials from CHD patients revealed a correlation between elevated inflammatory markers and comorbidities, indicating that addressing these inflammatory pathways could help reduce cardiovascular events in affected individuals.
Article Synopsis
- A study aimed to investigate long-term outcomes of minimally invasive mitral valve surgery (MVS) for elderly patients (≥70 years) with secondary mitral valve regurgitation (MR), especially those with heart failure and co-morbidities.
- The research analyzed a group of 67 patients who underwent MVS through different surgical approaches, focusing on survival rates, operational success, and safety outcomes.
- Results showed promising medium-term effects of MVS, but the study highlighted the need for more data on long-term effectiveness to determine the best therapy for these high-risk patients.
Purpose: In absence of comprehensive data collection on traumatic brain injury (TBI), the German Society for Neurosurgery (DGNC) and the German Society for Trauma Surgery (DGU) developed a TBI databank for German-speaking countries.
Methods: From 2016 to 2020, the TBI databank DGNC/DGU was implemented as a module of the TraumaRegister (TR) DGU and tested in a 15-month pilot phase. Since its official launch in 2021, patients from the TR-DGU (intermediate or intensive care unit admission via shock room) with TBI (AIS head ≥ 1) can be enrolled.
Despite increasing options for treatment of castration-resistant prostate cancer, development of drug resistance is inevitable. The glucocorticoid receptor (GR) is a prime suspect for acquired therapy resistance, as prostate cancer (PCa) cells are able to increase GR signaling during anti-androgen therapy and thereby circumvent androgen receptor (AR)-blockade and cell death. As standard AR-directed therapies fail to block the GR and GR inhibitors might result in intolerable side effects, the identification of GR signature genes, which are better suited for a targeted approach, is of clinical importance.
View Article and Find Full Text PDFThe pathogenetic role of angiogenesis in interstitial lung diseases (ILDs) is controversial. This study represents the first investigation of the spatial complexity and molecular motifs of microvascular architecture in important subsets of human ILD. The aim of our study was to identify specific variants of neoangiogenesis in three common pulmonary injury patterns in human ILD.
View Article and Find Full Text PDFPractical clinical expertise is a crucial part of medical professionalism. Several studies have shown that medical students are poorly trained in practical skills during their undergraduate training. Even the students rated their own expertise in practical skills as poor.
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