Publications by authors named "Johannes Hensler"

Objective: In this study, we report our experience with the occurrence of diffusion-weighted imaging (DWI) lesions following aneurysm treatment with Woven EndoBridge (WEB) device and Contour Neurovascular System in elective settings. We compared both techniques in a retrospective single-center analysis, to investigate whether there are significant differences in the incidence of microemboli depending on the device used.

Materials And Methods: Sixty-two cases treated with Contour were retrospectively compared with 84 WEB cases.

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  • The contour neurovascular system (CNS) is a device used to treat specific types of brain aneurysms, but its metal components interfere with MRI imaging after implantation.
  • This study involved creating 3D models of aneurysms and testing different imaging methods, including CTA and MRI, to find effective non-invasive alternatives to the standard digital subtraction angiography (DSA).
  • Results showed that focused spectral CTA with metal artifact reduction provided clear imaging similar to DSA, making it a good option for follow-ups, while MRI was limited in assessing critical areas around the aneurysms post-implantation.
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  • A study was conducted to examine early degenerative spinal disc changes in elite female CrossFit athletes using advanced 3.0 Tesla MRI technology, comparing them to non-athlete controls.
  • The research involved 19 participants, including 9 elite athletes and 10 non-athletes, measuring the prevalence and grading of any spinal disc degeneration.
  • The findings revealed that there was no significant increase in degenerative disc disease among the athletes, suggesting that high-volume CrossFit training does not correlate with a higher risk of spinal disc changes.
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Introduction: Treatment of basilar apex aneurysms will remain challenging regarding the nobility of the parent vessel and their often wide-necked configuration. With endovascular techniques being the treatment approach of choice, novel intrasaccular flow-disruption devices constitute an endovascular embolization option. In this research, we report our experiences in embolizing basilar tip aneurysms with the novel Contour device.

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Objective: Describing spectrum, evolution, and clinical relationship of brain magnetic resonance imaging (MRI) findings in a large case series of children with febrile infection-related epilepsy syndrome (FIRES).

Methods: This retrospective study included 31 children with FIRES. Clinical data and MRI findings of the brain were evaluated.

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Background And Purpose: Treating aneurysms with intra-saccular flow disruption is a feasible alternative to coil-embolization. Besides the established WEB device, the novel Contour Neurovascular System has emerged as a potentially easier alternative regarding sizing and deployment. We report the learning curve experienced at our center from the first 48 patients treated with Contour and compared it with 48 consecutive WEB cases.

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Background: Intravenous thrombolysis (IVT) and endovascular mechanical thrombectomy therapy (MT) are well established in the treatment of acute ischemic stroke. It is currently unclear whether these treatments can be applied in patients with previous deep brain stimulation (DBS) surgery and how long the interval to the DBS operation should be.

Methods: Four patients with ischemic stroke and IVT or MT were included in this retrospective case series.

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  • The Contour device is an intrasaccular flow disruption tool originally for treating wide-neck bifurcation aneurysms but can also be used for those with a higher dome-to-neck ratio.
  • A study involving 42 patients found that embolization with the Contour device was faster and required less radiation compared to traditional coil embolization.
  • Complications and reintervention rates were lower with the Contour device, suggesting it may be a safer alternative for treating narrow-neck aneurysms.
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  • A new device called the contour neurovascular system has been created to treat intracranial aneurysms by reducing blood flow at the aneurysm neck.
  • The study tested different sizes of the contour device on patient-based aneurysm models using 2D digital subtraction angiography to measure flow diversion efficiency by calculating contrast washout time (WOT).
  • Results showed that the 5-mm contour had the longest WOT, indicating better performance, while the larger 11-mm and 14-mm contours had similar effectiveness in flow diversion.
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We aimed to study the impact of leukoaraiosis (LA) and blood pressure (BP) on clinical outcome, mortality and symptomatic intracerebral hemorrhage (sICH) in acute ischemic stroke (AIS) patients treated with mechanical thrombectomy (MT). We analyzed data retrospectively from 521 patients with anterior large vessel occlusion treated with MT. LA was dichotomized in 0-2 (absent-to-moderate) versus 3-4 (moderate-to-severe) according to the van Swieten scale.

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Purpose: Wide-necked bifurcation aneurysms, partially thrombosed, and recurrences of large and giant aneurysms are challenging to treat. We report our preliminary experience with a Contour-assisted coiling technique and discuss the periprocedural safety, feasibility, and effectiveness of the approach.

Methods: We retrospectively reviewed consecutive patients who received endovascular treatment for intracranial aneurysms with an intra-aneurysmal flow disruptor (Contour) at two neurovascular centres between October 2018 and December 2020 and identified patients treated with a combination of Contour and platinum coils.

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Purpose: Due to its high sensitivity and lack of radiation, MRI is often used to stage cerebral tumors in patients. In contrast, the relatively long examination times and the limited availability of MRI slots at the clinic might delay these examinations. The aim of this study was to compare an ultra-short MRI protocol with the routinely used standard protocol.

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  • The middle meningeal artery (MMA) appears like a high heel shoe print on MRI scans, which can reveal cranial dural arteriovenous fistulas (DAVFs) when it looks shinier and thicker than the opposite side.
  • A study analyzed 84 TOF-MRA exams to compare MMA diameters and signal intensities in patients with DAVFs versus those without, finding significant differences.
  • The novel "shiny high heel sign" and "thick high heel sign" have cut-off values for identifying DAVFs, showing high sensitivity and predictive value, suggesting that these indicators could improve detection using non-contrast MRI scans.
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Background:  Pseudotumor cerebri, also known as idiopathic intracranial hypertension, is a disorder of increased intracranial pressure of unknown etiology. Main symptom is headache which has a characteristic similar to other headache diseases, therefore the idiopathic intracranial hypertension often remains undetected. The incidence is 1/100 000 with the number of unreported cases being much higher.

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  • Braided flow diverters are complex devices used to treat brain aneurysms, and testing them effectively in lab settings has been challenging.
  • The study utilized patient-specific 3D-printed vascular models and advanced imaging techniques like 4D flow MRI and laser microscopy to analyze flow properties and mechanical characteristics of the diverters.
  • The results demonstrated that new methods enabled the accurate measurement of flow dynamics and mechanical forces in the diverters, providing fresh insights into their performance and design.
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Purpose: Non-contrast-enhanced (CE) magnetic resonance angiography (MRA) techniques are of considerable interest for diagnosing vascular diseases in the upper extremities owing to the possibility of repeated examinations, sufficient coverage of the measurement volume, and because possible side effects of administering iodine- or gadolinium-based contrast agents and radiation exposure can be avoided. The aim of this study was to investigate the feasibility of an optimized electrocardiogram (ECG) triggered Cartesian quiescent interval slice selective (QISS) technique for MRA of hand arteries.

Material And Methods: Both hands of 20 healthy volunteers (HVs) were examined using an optimized QISS-MRA pulse sequence at 1.

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Purpose: In the interventional treatment of cerebral aneurysms, flow diverter (FD) stents have played a significant role for more than a decade. Many studies have shown good aneurysm occlusion rates and low complication profiles. However, feared complications include acute thrombotic vessel occlusion due to stenotic deformation of the FD during release, the so-called twisting.

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  • Flow models of intracranial aneurysms (IAs) were developed to test flow modulation devices (FMDs) using inexpensive methods and 4D flow MRI technology for noninvasive hemodynamic analysis.
  • The models were created using 3D printing from human radiological data and evaluated with various imaging techniques, showing that the geometry and flow characteristics closely matched in vivo conditions.
  • Results indicated that deploying FMDs significantly reduced the flow velocity in the IAs, demonstrating the models' effectiveness for testing treatments in a cost-effective manner.
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  • The study examines the effectiveness of the direct aspiration first pass technique (ADAPT) for thrombectomy in patients with acute ischemic stroke, comparing 6F ADAPT alone and 5F ADAPT with an 8F balloon guide catheter (BGC).
  • Experiments conducted on two types of clots demonstrated that full recanalization was achieved in all cases, with high success rates for both techniques in different clot types and minimal distal emboli.
  • The findings suggest that 6F ADAPT is just as effective as the 5F ADAPT with BGC, making it a preferable option in complex vascular anatomies.
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The use of virtual reality trainers for teaching minimally invasive surgical techniques has been established for a long time in conventional laparoscopy as well as robotic surgery. The aim of the present study was to evaluate the impact of reproducible disruptive factors on the surgeon's work. In a cross-sectional investigation, surgeons were tested with regard to the impact of different disruptive factors when doing exercises on a robotic-surgery simulator (Mimic Flex VR).

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Purpose: To evaluate the occurrence and risk factors of acute in-stent thrombosis or stent occlusion in patients with tandem occlusions receiving intracranial mechanical thrombectomy and emergent extracranial internal carotid artery stenting with a dual layer carotid stent.

Methods: Multicenter retrospective data collection and analysis of stroke databases of seven comprehensive stroke centers from three European countries.

Results: Overall, 160 patients (mean (SD) age 66 (12) years; 104 men (65%); median (IQR) baseline NIHSS 14 (9-18); IV lysis, n=97 (60.

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Objectives: Unilateral pulmonary oedema (UPE) is a rare but potentially life-threatening complication that has been described after minimally invasive mitral valve surgery (MICS). Over the last 8 years, we have witnessed, in our institution, several cases of severe UPE requiring immediate postoperative extracorporeal life support after MICS. Reviewing the available literature, data regarding this complication after MICS are rare.

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Introduction: Spontaneous dissections of intracranial arteries are rare, but important causes of stroke, especially in younger patients. Dissections of the anterior cerebral artery (ACA) have been reported only very rarely in the European and North American populations but might be more prevalent than previously thought.

Methods: This paper describes the presenting pattern of the disease, the clinical and imaging findings, as well as endovascular therapeutical options with respect to a meta-analysis of cases reported in the literature.

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Introduction: Hypothermia improves survival and neurological recovery after cardiac arrest. Pro-inflammatory cytokines have been implicated in focal cerebral ischemia/reperfusion injury. It is unknown whether cardiac arrest also triggers the release of cerebral inflammatory molecules, and whether therapeutic hypothermia alters this inflammatory response.

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