Publications by authors named "Johannes Gg Dobbe"

Article Synopsis
  • - This study compares two types of coordinate systems used to analyze foot movement: marker-based coordinate systems (MCSs) and bone morphology-based coordinate systems (BCSs), focusing on how they relate to the foot's underlying anatomy.
  • - The research involved placing markers on the feet of fifteen healthy adults and using CT scans to examine the orientation differences between MCSs and BCSs, measured in angles like helical and 3D Euler.
  • - Findings revealed that MCSs were often misaligned with BCSs, particularly showing different orientations in the hindfoot and forefoot, and only certain models (RFM and AFM) effectively captured variability in foot bone poses across individuals.
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Background: Image noise, object repositioning, initial manual image alignment, and stitching of different volumes, i.e. anatomical regions may all affect the stitching error of fused cone-beam computed tomography (CBCT) images.

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Regular blood transfusion is the cornerstone of care for patients with red blood cell (RBC) disorders such as thalassaemia or sickle-cell disease. With repeated transfusion, alloimmunisation often occurs due to incompatibility at the level of minor blood group antigens. We use CRISPR-mediated genome editing of an immortalised human erythroblast cell line (BEL-A) to generate multiple enucleation competent cell lines deficient in individual blood groups.

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