Overexpression of activated protein C hampers bacterial dissemination during pneumococcal pneumonia.

Background: During pneumonia, inflammation and coagulation are activated as part of anti-bacterial host defense. Activated protein C (APC) has anticoagulant and anti-inflammatory properties and until recently was a registered drug for the treatment of severe sepsis. Streptococcus (S.

The effect of inflammation on coagulation and vice versa.

Purpose Of Review: In infection, inflammation is frequently accompanied by a disturbance of the normal hemostatic balance provided by procoagulant and anticoagulant mechanisms. This review summarizes recently acquired knowledge on the bimodal interactions between coagulation and inflammation in infection.

Recent Findings: Infection elicits inflammation-induced coagulation via tissue factor.